Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | PPARA | Q07869 | 3/20 | 0.42 |
| ▸ | PPARG | P37231 | 2/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9780706 | 1.00 | KMT2A (0.49) | KMT2ACYP1A2GAACYP2C9PKM | |
| SCHEMBL9500663 | 0.90 | TSHR (0.50) | KMT2ACYP1A2GAACYP2C9PKM | |
| SCHEMBL20562032 | 0.85 | CA1 (0.41) | KMT2ACYP1A2GAACYP2C9PKM | |
| SCHEMBL18128002 | 0.84 | MAPT (0.52) | KMT2ACYP1A2GAACYP2C9PKM | |
| SCHEMBL10013407 | 0.83 | CXCL8 (0.42) | KMT2ACYP1A2TSHRADRA2AADRA2B | |
| SCHEMBL400373 | 0.83 | CXCL8 (0.42) | KMT2ACYP1A2TSHRADRA2AADRA2B | |
| SCHEMBL10013408 | 0.83 | CXCL8 (0.42) | KMT2ACYP1A2TSHRADRA2AADRA2B | |
| SCHEMBL10013418 | 0.81 | KMT2A (0.47) | KMT2AADRA2AADRA2BADRA2CHTR1A | |
| SCHEMBL1019372 | 0.81 | KMT2A (0.59) | KMT2ACYP1A2GAACYP2C9PKM | |
| SCHEMBL1576594 | 0.81 | KMT2A (0.59) | KMT2ACYP1A2GAACYP2C9PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0081748-B1 | PROCESS FOR THE PREPARATION OF (-)-2-(1-(2,6-DICHLOROPHENOXY)-ETHYL)-1,3-DIAZACYCLOPENT-2-ENE | A. Nattermann & Cie. GmbH (DE) | 1987-02-25 | — | — | EP | claimed |
| EP-0082364-B1 | (+)-2-(1-(2,6-DICHLOROPHENOXY)-ETHYL)-1,3-DIAZACYCLOPENT-2-ENE, PROCESS FOR ITS PREPARATION AND ITS USE IN PHARMACEUTICAL COMPOSITIONS | A. Nattermann & Cie. GmbH (DE) | 1986-04-23 | — | — | EP | claimed |
| CN-115707690-A | 3-isoxazolidinone compound, preparation method thereof, weeding composition and application | 青岛清原化合物有限公司 | 2023-02-21 | — | — | CN | disclosed |
| EP-3986869-A1 | A PROCESS FOR THE SYNTHESIS OF LOFEXIDINE | Procos S.p.A. (IT) | 2022-04-27 | — | — | EP | disclosed |
| EP-3986869-A1 | A PROCESS FOR THE SYNTHESIS OF LOFEXIDINE | Procos S.p.A. (IT) | 2022-04-27 | — | — | EP | disclosed |
| WO-2020254580-A1 | A PROCESS FOR THE SYNTHESIS OF LOFEXIDINE | PROCOS S.P.A. (IT) | 2020-12-24 | — | — | WO | disclosed |
| WO-2020254580-A1 | A PROCESS FOR THE SYNTHESIS OF LOFEXIDINE | PROCOS S.P.A. (IT) | 2020-12-24 | — | — | WO | disclosed |
| EP-0257378-B1 | PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND MEDICAMENTS CONTAINING THESE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1991-07-03 | — | — | EP | disclosed |
| US-5010060-A | Method of treating herpes simplex viral infection employing pyrimidine derivatives | HOFFMANN-LA ROCHE INC. (US) | 1991-04-23 | — | — | US | disclosed |
| US-4851519-A | AMIDO NUCLEOSIDES, VIRICIDES | HOFFMANN-LA ROCHE INC. (US) | 1989-07-25 | — | — | US | disclosed |
| EP-0257378-A1 | Pyrimidine derivatives, their preparation and medicaments containing these derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1988-03-02 | — | — | EP | disclosed |
| EP-0081748-B1 | PROCESS FOR THE PREPARATION OF (-)-2-(1-(2,6-DICHLOROPHENOXY)-ETHYL)-1,3-DIAZACYCLOPENT-2-ENE | A. Nattermann & Cie. GmbH (DE) | 1987-02-25 | — | — | EP | disclosed |
| EP-0082364-B1 | (+)-2-(1-(2,6-DICHLOROPHENOXY)-ETHYL)-1,3-DIAZACYCLOPENT-2-ENE, PROCESS FOR ITS PREPARATION AND ITS USE IN PHARMACEUTICAL COMPOSITIONS | A. Nattermann & Cie. GmbH (DE) | 1986-04-23 | — | — | EP | disclosed |
| US-4518783-A | Process for producing (-)-2-[1-(2,6-dichlorophenoxy)-ethyl]-1,3-diazacyclopent-2-ene | A. NATTERMANN & CIE GMBH (DE) | 1985-05-21 | — | — | US | disclosed |
| US-4443464-A | (+)-2-[1-(2,6-Dichlorophenoxy)-ethyl]-1,3-diazacyclopent-2-ene and the method for the treatment of human beings suffering from nervous disarrangements, in particular migraine | A. NATTERMANN & CIE GMBH (DE) | 1984-04-17 | — | — | US | disclosed |
| EP-0082364-A2 | (+)-2-(1-(2,6-dichlorophenoxy)-ethyl)-1,3-diazacyclopent-2-ene, process for its preparation and its use in pharmaceutical compositions | A. Nattermann & Cie. GmbH (DE) | 1983-06-29 | — | — | EP | disclosed |
| EP-0081748-A2 | Process for the preparation of (-)-2-(1-(2,6-dichlorophenoxy)-ethyl)-1,3-diazacyclopent-2-ene | A. Nattermann & Cie. GmbH (DE) | 1983-06-22 | — | — | EP | disclosed |