Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCL8 | P10145 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | OGG1 | O15527 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | PNMT | P11086 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10013407 | 1.00 | CXCL8 (0.42) | CXCL8KMT2AOGG1CYP1A2CYP3A4 | |
| SCHEMBL10013408 | 1.00 | CXCL8 (0.42) | CXCL8KMT2AOGG1CYP1A2CYP3A4 | |
| SCHEMBL9780706 | 0.83 | KMT2A (0.49) | CXCL8KMT2ACYP1A2ADRA2AADRA2B | |
| SCHEMBL9780698 | 0.83 | KMT2A (0.49) | CXCL8KMT2ACYP1A2ADRA2AADRA2B | |
| SCHEMBL12656301 | 0.82 | KMT2A (0.46) | CXCL8KMT2ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL12656438 | 0.82 | KMT2A (0.46) | CXCL8KMT2ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL16244235 | 0.80 | KMT2A (0.57) | KMT2AALDH1A1LMNAPOLBHPGD | |
| SCHEMBL10013418 | 0.80 | KMT2A (0.47) | CXCL8KMT2AOGG1ADRA2AADRA2B | |
| Hydrochloric Acid SCHEMBL2720751 | 0.78 | LMNA (0.44) | KMT2ACYP1A2CYP3A4CYP2D6NFKB1 | |
| SCHEMBL10013411 | 0.77 | LMNA (0.48) | KMT2ACYP1A2ALDH1A1LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8101779-B2 | Enantioselective synthesis of (+) and (–)-2-[1-(2,6-dichlorophenoxy)-ethyl]-1,3-diazacyclopent-2-ene | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2012-01-24 | — | — | US | disclosed |
| US-20100087657-A1 | ENANTIOSELECTIVE SYNTHESIS OF (+) AND (-)-2-[1-(2,6-DICHLOROPHENOXY)-ETHYL]-1,3-DIAZACYCLOPENT-2-3ENE | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2010-04-08 | — | — | US | disclosed |
| EP-0081748-B1 | PROCESS FOR THE PREPARATION OF (-)-2-(1-(2,6-DICHLOROPHENOXY)-ETHYL)-1,3-DIAZACYCLOPENT-2-ENE | A. Nattermann & Cie. GmbH (DE) | 1987-02-25 | — | — | EP | disclosed |
| EP-0082364-B1 | (+)-2-(1-(2,6-DICHLOROPHENOXY)-ETHYL)-1,3-DIAZACYCLOPENT-2-ENE, PROCESS FOR ITS PREPARATION AND ITS USE IN PHARMACEUTICAL COMPOSITIONS | A. Nattermann & Cie. GmbH (DE) | 1986-04-23 | — | — | EP | disclosed |
| US-4518783-A | Process for producing (-)-2-[1-(2,6-dichlorophenoxy)-ethyl]-1,3-diazacyclopent-2-ene | A. NATTERMANN & CIE GMBH (DE) | 1985-05-21 | — | — | US | disclosed |
| US-4443464-A | (+)-2-[1-(2,6-Dichlorophenoxy)-ethyl]-1,3-diazacyclopent-2-ene and the method for the treatment of human beings suffering from nervous disarrangements, in particular migraine | A. NATTERMANN & CIE GMBH (DE) | 1984-04-17 | — | — | US | disclosed |
| EP-0081748-A2 | Process for the preparation of (-)-2-(1-(2,6-dichlorophenoxy)-ethyl)-1,3-diazacyclopent-2-ene | A. Nattermann & Cie. GmbH (DE) | 1983-06-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100087657-A1 | ENANTIOSELECTIVE SYNTHESIS OF (+) AND (-)-2-[1-(2,6-DICHLOROPHENOXY)-ETHYL]-1,3-DIAZACYCLOPENT-2-3ENE | CYP2E1, CYP2D6, CYP2C9 | CXCL8 3482/4885KMT2A 796/4885OGG1 831/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.