Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 18/20 | 0.52 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.51 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.51 |
| ▸ | PDE2A | O00408 | 1/20 | 0.51 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.50 |
| ▸ | MAOA | P21397 | 1/20 | 0.50 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9781475 | 0.93 | PDE3B (0.59) | GPR119PDE3BPDE3APDE2AABCB11 | |
| SCHEMBL9781454 | 0.88 | PDE3B (0.64) | GPR119PDE3BPDE3AABCB11MAOA | |
| SCHEMBL9781456 | 0.79 | PDE3B (0.77) | GPR119PDE3BPDE3AABCB11MAOA | |
| SCHEMBL8264680 | 0.77 | PDE3B (0.64) | GPR119PDE3BPDE3AABCB11MAOA | |
| SCHEMBL3440919 | 0.77 | FBP1 (0.62) | PDE3BPDE3AABCB11MAOAADORA2A | |
| SCHEMBL7712293 | 0.77 | PDE3B (0.61) | GPR119PDE3BPDE3AABCB11MAOA | |
| SCHEMBL7295810 | 0.76 | GPR119 (0.52) | GPR119PDE3BPDE3APDE2A | |
| Hydrochloric Acid SCHEMBL7322526 | 0.76 | PDE3B (0.63) | GPR119PDE3BPDE3AABCB11MAOA | |
| SCHEMBL10769306 | 0.76 | PDE3B (0.60) | GPR119PDE3BPDE3AABCB11MAOA | |
| SCHEMBL9781503 | 0.76 | KCNH2 (0.51) | GPR119PDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5026705-A | Benzimidazolylpyridazinones | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1991-06-25 | — | — | US | disclosed |
| US-4923869-A | INOTROPIC, VASODILATING, AND ANTITHROMBOTIC AGENTS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1990-05-08 | — | — | US | disclosed |
| EP-0193013-A2 | Benzimidazolyl-pyridazinones | MERCK PATENT GmbH (DE) | 1986-09-03 | — | — | EP | disclosed |