Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 2/20 | 0.54 |
| ▸ | PDE3B | Q13370 | 12/20 | 0.50 |
| ▸ | PDE3A | Q14432 | 12/20 | 0.50 |
| ▸ | PDE4A | P27815 | 3/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.48 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.47 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7316119 | 0.88 | PDE3B (0.63) | BRD4PDE3BPDE3APDE4APDE4B | |
| SCHEMBL9781456 | 0.76 | PDE3B (0.77) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL9781454 | 0.76 | PDE3B (0.64) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10519316 | 0.75 | GPR119 (0.69) | GPR119 | |
| SCHEMBL11331025 | 0.75 | PDE3B (0.56) | BRD4PDE3BPDE3APDE4APDE4B | |
| SCHEMBL10281544 | 0.75 | PDE3B (0.57) | BRD4PDE3BPDE3APDE4APDE4B | |
| SCHEMBL7321067 | 0.74 | BRD4 (0.56) | BRD4PDE3BPDE3APDE4APDE4B | |
| SCHEMBL7352164 | 0.74 | PDE3B (0.52) | BRD4PDE3BPDE3APDE4APDE4B | |
| SCHEMBL11322299 | 0.73 | PDE3B (0.54) | BRD4PDE3BPDE3APDE4APDE4B | |
| SCHEMBL2582984 | 0.73 | GPR119 (0.82) | GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4923869-A | INOTROPIC, VASODILATING, AND ANTITHROMBOTIC AGENTS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1990-05-08 | — | — | US | claimed |
| EP-0193013-B1 | BENZIMIDAZOLYL-PYRIDAZINONES | MERCK PATENT GmbH (DE) | 1989-04-19 | — | — | EP | claimed |
| US-5026705-A | Benzimidazolylpyridazinones | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1991-06-25 | — | — | US | disclosed |
| US-4923869-A | INOTROPIC, VASODILATING, AND ANTITHROMBOTIC AGENTS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1990-05-08 | — | — | US | disclosed |
| EP-0193013-A2 | Benzimidazolyl-pyridazinones | MERCK PATENT GmbH (DE) | 1986-09-03 | — | — | EP | disclosed |