Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 5/20 | 0.52 |
| ▸ | PDE3A | Q14432 | 5/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | GFER | P55789 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | GPR119 | Q8TDV5 | 9/20 | 0.50 |
| ▸ | BRD4 | O60885 | 2/20 | 0.49 |
| ▸ | PDE4A | P27815 | 1/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11286702 | 0.92 | GPR119 (0.52) | PDE3BPDE3AGPR119PDE4APDE4B | |
| SCHEMBL7321067 | 0.76 | BRD4 (0.56) | PDE3BPDE3AGPR119BRD4PDE4A | |
| SCHEMBL7312860 | 0.76 | BRD4 (0.74) | PDE3BPDE3AGPR119BRD4 | |
| SCHEMBL9781546 | 0.74 | BRD4 (0.54) | PDE3BPDE3AGPR119BRD4PDE4A | |
| SCHEMBL7316119 | 0.72 | PDE3B (0.63) | PDE3BPDE3AKDM4EALDH1A1MAPT | |
| SCHEMBL10353457 | 0.71 | PDE3B (0.71) | PDE3BPDE3AMAPTPDE4APDE4B | |
| SCHEMBL9688044 | 0.71 | PDE3B (0.64) | PDE3BPDE3AALDH1A1MAPTGPR119 | |
| SCHEMBL9516140 | 0.71 | PDE3B (0.57) | PDE3BPDE3AALDH1A1MAPTGPR119 | |
| SCHEMBL13904436 | 0.70 | ALDH1A1 (0.56) | KDM4EALDH1A1MAPTGFERTDP1 | |
| SCHEMBL16157195 | 0.70 | PDE3B (0.68) | PDE3BPDE3AALDH1A1MAPTPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4361563-A | CARDIOTONIC, ANTITHROMBOTIC | DR. KARL THOMAE GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1982-11-30 | — | — | US | disclosed |
| EP-0008391-A1 | Benzimidazoles, their preparation and pharmaceutical compositions containing them | Dr. Karl Thomae GmbH (DE) | 1980-03-05 | — | — | EP | disclosed |