Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | GABRA2 | P47869 | 7/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 7/20 | 0.41 |
| ▸ | GABRP | O00591 | 6/20 | 0.41 |
| ▸ | GABRD | O14764 | 6/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 6/20 | 0.41 |
| ▸ | GABRB1 | P18505 | 6/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 6/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 6/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 6/20 | 0.41 |
| ▸ | GABRA3 | P34903 | 6/20 | 0.41 |
| ▸ | GABRA4 | P48169 | 6/20 | 0.41 |
| ▸ | GABRE | P78334 | 6/20 | 0.41 |
| ▸ | GABRA6 | Q16445 | 6/20 | 0.41 |
| ▸ | GABRG1 | Q8N1C3 | 6/20 | 0.41 |
| ▸ | GABRG3 | Q99928 | 6/20 | 0.41 |
| ▸ | GABRQ | Q9UN88 | 6/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30777281 | 1.00 | CA1 (0.44) | CA1CA2CA9GABRA2GABRB2 | |
| SCHEMBL15512406 | 0.88 | CA1 (0.37) | CA1CA2CA9GABRA2GABRB2 | |
| SCHEMBL30439201 | 0.84 | ALDH1A1 (0.50) | CA1CA2CA9GABRA2GABRB2 | |
| SCHEMBL967220 | 0.84 | ALDH1A1 (0.50) | CA1CA2CA9GABRA2GABRB2 | |
| SCHEMBL2159314 | 0.84 | ALDH1A1 (0.39) | CA1CA2CA9GABRA2GABRB2 | |
| Hydrochloric Acid SCHEMBL29123267 | 0.82 | ALDH1A1 (0.48) | CA1CA2CA9GABRA2GABRB2 | |
| Nitrogen SCHEMBL28714282 | 0.80 | ALDH1A1 (0.46) | CA1CA2CA9GABRA2GABRB2 | |
| SCHEMBL29746198 | 0.78 | ALDH1A1 (0.48) | GABRA2GABRB2GABRPGABRDGABRA1 | |
| SCHEMBL904486 | 0.78 | ALDH1A1 (0.48) | GABRA2GABRB2GABRPGABRDGABRA1 | |
| SCHEMBL22366856 | 0.77 | GABRB3 (0.44) | GABRA2GABRB2GABRPGABRDGABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230066771-A1 | NUCLEAR RECEPTOR MODULATORS | ABBVIE INC (US) | 2023-03-02 | — | — | US | disclosed |
| US-20210130293-A1 | NUCLEAR RECEPTOR MODULATORS | ABBVIE INC (US) | 2021-05-06 | — | — | US | disclosed |
| EP-3636643-A1 | NUCLEAR RECEPTOR MODULATORS (ROR) FOR THE TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES | AbbVie Inc. (US) | 2020-04-15 | — | — | EP | disclosed |
| US-20190055196-A1 | NUCLEAR RECEPTOR MODULATORS | ABBVIE INC (US) | 2019-02-21 | — | — | US | disclosed |
| US-10160731-B2 | Method for preparing 3-trifluoromethyl chalcones | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2018-12-25 | — | — | US | disclosed |
| US-10106501-B2 | Nuclear receptor modulators | ABBVIE INC. (US) | 2018-10-23 | — | — | US | disclosed |
| US-20180222873-A1 | METHOD FOR PREPARING 3-TRIFLUOROMETHYL CHALCONES | CORTEVA AGRISCIENCE LLC | 2018-08-09 | — | — | US | disclosed |
| EP-3307734-A1 | NUCLEAR RECEPTOR MODULATORS | AbbVie Inc. (US) | 2018-04-18 | — | — | EP | disclosed |
| US-9938248-B2 | Method for preparing 3-trifluoromethyl chalcones | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2018-04-10 | — | — | US | disclosed |
| US-20180057468-A1 | METHOD FOR PREPARING 3-TRIFLUOROMETHYL CHALCONES | CORTEVA AGRISCIENCE LLC | 2018-03-01 | — | — | US | disclosed |
| EP-2260016-B1 | METHOD FOR PREPARING 3-TRIFLUOROMETHYL CHALCONES | DU PONT (US) | 2015-09-02 | — | — | EP | disclosed |
| US-20150210654-A1 | METHOD FOR PREPARING 3-TRIFLUOROMETHYL CHALCONES | DU PONT (US) | 2015-07-30 | — | — | US | disclosed |
| US-9035101-B2 | Method for preparing 3-trifluoromethyl chalcones | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2015-05-19 | — | — | US | disclosed |
| US-20140155617-A1 | METHOD FOR PREPARING 3-TRIFLUOROMETHYL CHALCONES | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2014-06-05 | — | — | US | disclosed |
| EP-2706050-A1 | 1-Chloro-3-iodo-5-(trifluoromethyl)benzene | E. I. du Pont de Nemours and Company (US) | 2014-03-12 | — | — | EP | disclosed |
| EP-2706053-A1 | Method for preparing 2-trifluoromethyl ketones | E. I. du Pont de Nemours and Company (US) | 2014-03-12 | — | — | EP | disclosed |
| US-8546618-B2 | Method for preparing 3-trifluoromethyl chalcones | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2013-10-01 | — | — | US | disclosed |
| US-20110009638-A1 | METHOD FOR PREPARING 3-TRIFLUOROMETHYL CHALCONES | E.I. DU PONT DE NEMOURS AND COMPANY (DE) | 2011-01-13 | — | — | US | disclosed |
| EP-2260016-A2 | METHOD FOR PREPARING 3-TRIFLUOROMETHYL CHALCONES | E. I. du Pont de Nemours and Company (US) | 2010-12-15 | — | — | EP | disclosed |
| WO-2009126668-A2 | METHOD FOR PREPARING 3-TRIFLUOROMETHYL CHALCONES | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2009-10-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140155617-A1 | METHOD FOR PREPARING 3-TRIFLUOROMETHYL CHALCONES | NR3C2, RAE1, SULT1E1 | CA1 564/4885CA2 450/4885CA9 1300/4885 |
| US-10160731-B2 | Method for preparing 3-trifluoromethyl chalcones | NR3C2, CYP4A11, RAE1 | CA1 864/4885CA2 745/4885CA9 1454/4885 |
| US-20180057468-A1 | METHOD FOR PREPARING 3-TRIFLUOROMETHYL CHALCONES | NR3C2, CYP4A11, RAE1 | CA1 864/4885CA2 745/4885CA9 1454/4885 |
| US-20150210654-A1 | METHOD FOR PREPARING 3-TRIFLUOROMETHYL CHALCONES | NR3C2, CYP4A11, RAE1 | CA1 864/4885CA2 745/4885CA9 1454/4885 |
| US-20110009638-A1 | METHOD FOR PREPARING 3-TRIFLUOROMETHYL CHALCONES | NR3C2, CYP4A11, RAE1 | CA1 864/4885CA2 745/4885CA9 1454/4885 |
| US-10106501-B2 | Nuclear receptor modulators | NR1I2, NR1H2, NR5A2 | CA1 4477/4885CA2 2386/4885CA9 3995/4885 |
| US-20180222873-A1 | METHOD FOR PREPARING 3-TRIFLUOROMETHYL CHALCONES | NR3C2, CYP4A11, RAE1 | CA1 864/4885CA2 745/4885CA9 1454/4885 |
| US-20210130293-A1 | NUCLEAR RECEPTOR MODULATORS | NR1I2, NR1H2, NR5A2 | CA1 4477/4885CA2 2386/4885CA9 3995/4885 |
| US-20230066771-A1 | NUCLEAR RECEPTOR MODULATORS | NR1I2, NR1H2, NR5A2 | CA1 4477/4885CA2 2386/4885CA9 3995/4885 |
| US-20190055196-A1 | NUCLEAR RECEPTOR MODULATORS | NR1I2, NR1H2, NR5A2 | CA1 4477/4885CA2 2386/4885CA9 3995/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.