Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
| ▸ | CTSB | P07858 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | TDO2 | P48775 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8192014 | 0.83 | TDP1 (0.46) | TDP1TSHRSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL8498370 | 0.81 | ALDH1A1 (0.42) | TDP1TSHRSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL8566533 | 0.77 | ALDH1A1 (0.53) | TDP1TSHRALDH1A1KDM4EMAPT | |
| SCHEMBL9501122 | 0.77 | TDP1 (0.50) | TDP1TSHRSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL2773204 | 0.76 | TDP1 (0.54) | TDP1TSHRSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL5055510 | 0.75 | TDP1 (0.39) | TDP1TSHRSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL16856847 | 0.75 | TDP1 (0.39) | TDP1TSHRSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL12898049 | 0.75 | TDP1 (0.39) | TDP1TSHRSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL29401720 | 0.74 | TDP1 (0.52) | TDP1TSHRSMN1; SMN2ALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL27643164 | 0.74 | TDP1 (0.52) | TDP1TSHRSMN1; SMN2ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103613581-A | Preparation method for Dexiansoprazole | SHANDONG INST PHARMACEUTICAL INDUSTRY | 2014-03-05 | — | — | CN | disclosed |
| US-4981861-A | ANTIULCER | HOFFMANN-LA ROCHE INC. (US) | 1991-01-01 | — | — | US | disclosed |
| US-4950677-A | ANTIULCER AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1990-08-21 | — | — | US | disclosed |
| EP-0304624-A2 | Benzimidazol-2-yl-pyridinum compounds | F. HOFFMANN-LA ROCHE AG (CH) | 1989-03-01 | — | — | EP | disclosed |
| US-4766133-A | ANTIULCER AGENTS | HOFFMAN-LA ROCHE INC. (US) | 1988-08-23 | — | — | US | disclosed |
| EP-0214479-A2 | Benzimidazol-2-ylpyridinium compounds | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1987-03-18 | — | — | EP | disclosed |
| US-4634710-A | ANTIULCER, ANTISECRETORY | HOFFMANN-LA ROCHE INC. (US) | 1987-01-06 | — | — | US | disclosed |
| CN-85103357-A | The method for making of tricyclic imidazole derivatives and acid salt thereof | — | 1986-11-12 | — | — | CN | disclosed |
| EP-0163842-A1 | Tricyclic imidazole derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1985-12-11 | — | — | EP | disclosed |