Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.47 |
| ▸ | ADRB2 known ✓ | P07550 | 1/20 | 0.39 |
| ▸ | ADRA2B known ✓ | P18089 | 1/20 | 0.39 |
| ▸ | ADRA2C known ✓ | P18825 | 1/20 | 0.39 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.39 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.39 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.39 |
| ▸ | CDC25C | P30307 | 3/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.43 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | CA4 | P22748 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL9786026 | 0.84 | SLC2A1 (0.48) | CHRM2KCNH2SLC2A1ADRB2ADORA3 | |
| Bromide SCHEMBL9786002 | 0.84 | SLC2A1 (0.43) | KCNH2SLC2A1CA12CA2ADRB2 | |
| Bromide SCHEMBL9786042 | 0.84 | SLC2A1 (0.43) | KCNH2SLC2A1CA12CA2ADRB2 | |
| Bromide SCHEMBL9786063 | 0.84 | SLC2A1 (0.43) | KCNH2SLC2A1CA12CA2ADRB2 | |
| Bromide SCHEMBL9786053 | 0.82 | SLC2A1 (0.43) | KCNH2SLC2A1CA12CA2ADRB2 | |
| Bromide SCHEMBL9786103 | 0.82 | SLC2A1 (0.47) | KCNH2SLC2A1ADRB2ADORA3CHRM1 | |
| Bromide SCHEMBL7280733 | 0.82 | ADRB2 (0.56) | KCNH2SLC2A1ADRB2ADORA3CHRM1 | |
| SCHEMBL9786076 | 0.81 | SLC2A1 (0.44) | KCNH2SLC2A1CA12CA2ADRB2 | |
| SCHEMBL7292774 | 0.81 | KCNH2 (0.46) | CDC25CCHRM2KCNH2SLC2A1CA12 | |
| SCHEMBL7280271 | 0.81 | ADRB2 (0.57) | KCNH2SLC2A1ADRB2ADORA3CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5023378-A | Hypotensive agents, antiischemic agents, urogenital disorders | GLAXO GROUP LIMITED (GB) | 1991-06-11 | — | — | US | disclosed |
| EP-0188361-A1 | Amine derivatives | GLAXO GROUP LIMITED (GB) | 1986-07-23 | — | — | EP | disclosed |