Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 1/20 | 0.36 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.30 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.30 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.30 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.30 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.30 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.30 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10747388 | 0.75 | — | — | |
| SCHEMBL6677747 | 0.71 | ALDH1A1 (0.41) | — | |
| Alanine SCHEMBL10952534 | 0.70 | CYP1A2 (0.35) | NOS2 | |
| SCHEMBL29016737 | 0.70 | NOS2 (0.35) | NOS2 | |
| SCHEMBL8411934 | 0.69 | ALDH1A1 (0.44) | NOS2 | |
| SCHEMBL5838870 | 0.68 | GRIN2D (0.33) | NOS2GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL3082960 | 0.67 | — | — | |
| SCHEMBL508592 | 0.67 | — | — | |
| SCHEMBL23493150 | 0.66 | ELANE (0.55) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL15679080 | 0.66 | ELANE (0.55) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111154704-B | Serratia marcescens mutant strain and method for producing histidine by fermentation | 河南巨龙生物工程股份有限公司 | 2023-04-11 | — | — | CN | disclosed |
| CN-111154704-A | Serratia marcescens mutant strain and method for producing histidine by fermentation | 河南巨龙生物工程股份有限公司 | 2020-05-15 | — | — | CN | disclosed |
| CN-105307686-B | Modulation of structured polypeptide specificity | 拜斯科阿迪有限公司 | 2019-05-28 | — | — | CN | disclosed |
| CN-105307686-A | Modulation of structured polypeptide specificity | BICYCLE THERAPEUTICS LTD | 2016-02-03 | — | — | CN | disclosed |
| US-7871808-B2 | Isolated microorganism having an ability to produce L-histidine | KYOWA HAKKO BIO CO., LTD. (JP) | 2011-01-18 | — | — | US | disclosed |
| EP-1085086-B1 | Method for producing L-histidine by fermentation using DNA gyrase inhibitor resistant bacterial strains | KYOWA HAKKO KOGYO KK (JP) | 2008-03-19 | — | — | EP | disclosed |
| EP-1085087-B1 | Method for producing L-histidine by fermentation using aminoquinoline resistant bacterial strains of the genus Escherichia | KYOWA HAKKO KOGYO KK (JP) | 2007-06-20 | — | — | EP | disclosed |
| US-20060194302-A1 | Method for producing amino acids by fermentation | KYOWA HAKKO BIO CO., LTD. (JP) | 2006-08-31 | — | — | US | disclosed |
| US-7067289-B1 | Method for producing histidine by fermentation with E. coli | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2006-06-27 | — | — | US | disclosed |
| US-6706517-B2 | GENERATING HISTIDINE IN BACTERIAL CULTURE; OBTAIN MICROORGANISM CAPABLE OF GENERATING HISTIDINE, CULTURE, RECOVER HISTIDINE | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2004-03-16 | — | — | US | disclosed |
| US-20020102665-A1 | Method for producing L-amino acids by fermentation | KYOWA HAKKO BIO CO., LTD. (JP) | 2002-08-01 | — | — | US | disclosed |
| US-6344347-B1 | PRODUCING L-HISTIDINE FROM A MUTANT ESCHERICHIA MICROORGANISM USING ULTRAVIOLET IRRADIATION AND TREATMENT WITH A MUTAGEN, THEN CULTURE THE MUTANT CELLS ON AGAR PLATES CONTAINING A DNA GYRASE INHIBITOR TO PREVENT PARENT STRAIN FROM GROWING | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2002-02-05 | — | — | US | disclosed |
| EP-1085087-A2 | Method for producing amino acids by fermentation using aminoquinoline resistant bacterial strains | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2001-03-21 | — | — | EP | disclosed |
| EP-1085086-A2 | Method for producing amino acids by fermentation using DNA gyrase inhibitor resistant bacterial strains | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2001-03-21 | — | — | EP | disclosed |