Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 7/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | HPGDS | O60760 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CES2 | O00748 | 1/20 | 0.38 |
| ▸ | CES1 | P23141 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7436437 | 0.85 | HPGD (0.44) | HPGDALDH1A1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL9787259 | 0.79 | HPGDS (0.45) | HPGDALDH1A1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL10876269 | 0.68 | HPGDS (0.42) | HPGDALDH1A1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL7434232 | 0.68 | HPGD (0.43) | HPGDALDH1A1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL182010 | 0.66 | CES2 (0.71) | HPGDALDH1A1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL10884329 | 0.66 | HPGD (0.40) | HPGDALDH1A1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL10877089 | 0.65 | MEN1 (0.56) | HPGDALDH1A1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL9787285 | 0.65 | HPGDS (0.46) | HPGDALDH1A1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL3183222 | 0.65 | ALDH1A1 (0.79) | HPGDALDH1A1RAB9ANPC1SMN1; SMN2 | |
| Leucine SCHEMBL29159313 | 0.62 | SLC7A5 (0.53) | HPGDALDH1A1RAB9ANPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4999365-A | Preventing damage which occurs to heart tissue when oxygen is reintroduced after a heart attack | MERRELL DOW PHARMACEUTICALS INC. (US) | 1991-03-12 | — | — | US | disclosed |
| EP-0284925-A2 | Use of imidazol-2-thiones for the preparation of a medicament for reducing myocardial stunning | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-10-05 | — | — | EP | disclosed |