Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Alcohol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 1/20 | 0.48 |
| ▸ | ADRB3 | P13945 | 11/20 | 0.44 |
| ▸ | ADRB1 | P08588 | 9/20 | 0.44 |
| ▸ | ADRB2 | P07550 | 8/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9787723 | 0.94 | ACACB (0.51) | ACACBADRB3ADRB1ADRB2CYP2D6 | |
| Oxalic Acid SCHEMBL9787718 | 0.88 | ACACB (0.52) | ACACBADRB3ADRB1ADRB2CYP2D6 | |
| SCHEMBL9787781 | 0.85 | ADRB3 (0.58) | ACACBADRB3ADRB1ADRB2CYP2D6 | |
| SCHEMBL9492053 | 0.85 | ADRB3 (0.50) | ACACBADRB3ADRB1ADRB2CYP2D6 | |
| Alcohol SCHEMBL9787776 | 0.84 | ADRB3 (0.51) | ADRB3ADRB1ALDH1A1 | |
| SCHEMBL9787764 | 0.79 | ADRB3 (0.54) | ADRB3ADRB1ADRB2CYP2D6ADRA1D | |
| Oxalic Acid SCHEMBL9787777 | 0.79 | ADRB3 (0.59) | ACACBADRB3ADRB1ADRB2CYP2D6 | |
| SCHEMBL9787784 | 0.78 | ADRB3 (0.54) | ADRB3ADRB1ADRB2 | |
| Alcohol SCHEMBL9787806 | 0.76 | ADRB3 (0.50) | ADRB3ADRB1 | |
| SCHEMBL9787803 | 0.72 | ACACB (0.63) | ACACBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5045567-A | Propanolamine derivatives having anti-diabetic effects | HOFFMANN-LA ROCHE INC. (US) | 1991-09-03 | — | — | US | disclosed |