Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 7/20 | 0.51 |
| ▸ | GCGR | P47871 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | PDE6D | O43924 | 1/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.36 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10433924 | 0.91 | HMGCR (0.57) | HMGCRGCGRALDH1A1CYP3A4PDE6D | |
| SCHEMBL10434205 | 0.91 | HMGCR (0.57) | HMGCRGCGRALDH1A1CYP3A4PDE6D | |
| SCHEMBL10129259 | 0.80 | HMGCR (0.48) | HMGCRALDH1A1CYP3A4PDE6DNR1I2 | |
| SCHEMBL17875116 | 0.80 | ADORA1 (0.41) | HMGCRGCGRALDH1A1CYP3A4PDE6D | |
| SCHEMBL9562922 | 0.78 | HMGCR (0.56) | HMGCRGCGRALDH1A1CYP3A4PDE6D | |
| SCHEMBL9788395 | 0.78 | DPP4 (0.45) | HMGCRALDH1A1PDE4DKMT2AMAPT | |
| SCHEMBL14762690 | 0.77 | HMGCR (0.41) | HMGCRGCGRALDH1A1CYP3A4PDE6D | |
| SCHEMBL17965454 | 0.77 | HMGCR (0.46) | HMGCRGCGRALDH1A1CYP3A4PDE6D | |
| SCHEMBL14762686 | 0.77 | HMGCR (0.41) | HMGCRGCGRALDH1A1CYP3A4PDE6D | |
| SCHEMBL17965453 | 0.77 | HMGCR (0.46) | HMGCRGCGRALDH1A1CYP3A4PDE6D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5026708-A | Pyrimidine type mevalonolactones | NISSAN CHEMICAL INDUSTRIES LTD. (JP) | 1991-06-25 | — | — | US | disclosed |
| WO-1990010624-A1 | PYRIMIDINE TYPE MEVALONOLACTONES | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 1990-09-20 | — | — | WO | disclosed |
| EP-0308736-A2 | Pyrimidine type mevalonolactones | NISSAN CHEMICAL INDUSTRIES LTD. (JP) | 1989-03-29 | — | — | EP | disclosed |