Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGK1 | P00558 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 2/20 | 0.42 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CKS1B | P61024 | 2/20 | 0.41 |
| ▸ | SKP1 | P63208 | 2/20 | 0.41 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.40 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
| ▸ | GBA1 | P04062 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL978820 | 0.87 | POLB (0.44) | POLBCKS1BSKP1SKP2KIT | |
| SCHEMBL20011912 | 0.81 | POLB (0.47) | ACHETLR9POLBCKS1BSKP1 | |
| SCHEMBL30060994 | 0.81 | POLB (0.47) | ACHETLR9POLBCKS1BSKP1 | |
| SCHEMBL20154158 | 0.80 | POLB (0.46) | ACHETLR9POLBCKS1BSKP1 | |
| SCHEMBL978369 | 0.80 | MAP4K4 (0.46) | TLR9POLBCKS1BSKP1SKP2 | |
| SCHEMBL977899 | 0.77 | TLR9 (0.57) | TLR9POLBCKS1BSKP1SKP2 | |
| SCHEMBL24753185 | 0.73 | PGK1 (0.55) | PGK1ACHETLR9SUV39H2KIT | |
| SCHEMBL24753174 | 0.73 | PGK1 (0.55) | PGK1ACHETLR9SUV39H2KIT | |
| SCHEMBL31143019 | 0.72 | HTR3B (0.57) | ACHEPOLBCKS1BSKP1SKP2 | |
| SCHEMBL19995252 | 0.72 | TLR9 (0.44) | TLR9POLBCKS1BSKP1SKP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8802672-B2 | Pyrimidinyl-piperazines useful as D3/D2 receptor ligands | RICHTER GEDEON NYRT. (HU) | 2014-08-12 | — | — | US | disclosed |
| EP-2132185-B1 | PYRIMIDINYL-PIPERAZINES USEFUL AS DOPAMINE D3/D2 RECEPTOR LIGANDS | RICHTER GEDEON NYRT (HU) | 2011-08-03 | — | — | EP | disclosed |
| US-20110112093-A1 | PYRIMIDINYL-PIPERAZINES USEFUL AS D3/D2 RECEPTOR LIGANDS | RICHTER GEDEON NYRT. | 2011-05-12 | — | — | US | disclosed |
| US-7875610-B2 | trans-N-(4-{2-[4-(5,6-dichloro-2-methylamino-pyrimidin-4-yl)-piperazin-1-yl]-ethyl]-cyclohexyl}-acetamide; for treating Parkinson's disease; reacting trans-(4-{4-[2-(4-amino-cyclohexyl)-ethyl]-piperazin-1-yl}-5,6-dichloro-pyrimidin-2-yl)-methyl-amine trihydrochloride with acetyl chloride | RICHTER GEDEON NYRT. (HU) | 2011-01-25 | — | — | US | disclosed |
| EP-2132185-A2 | PYRIMIDINYL-PIPERAZINES USEFUL AS DOPAMINE D3/D2 RECEPTOR LIGANDS | Richter Gedeon NYRT (HU) | 2009-12-16 | — | — | EP | disclosed |
| US-20090143398-A1 | PYRIMIDINYL-PIPERAZINES USEFUL AS D3/D2 RECEPTOR LIGANDS | RICHTER GEDEON NYRT. (HU) | 2009-06-04 | — | — | US | disclosed |
| WO-2008125891-A2 | PYRIMIDINYL-PIPERAZINES USEFUL AS DOPAMINE D3 /D2 RECEPTOR LIGANDS | RICHTER GEDEON NYRT (HU) | 2008-10-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110112093-A1 | PYRIMIDINYL-PIPERAZINES USEFUL AS D3/D2 RECEPTOR LIGANDS | DRD2, DRD3, AVPR2 | PGK1 3665/4885ACHE 2921/4885TLR9 1561/4885 |
| US-20090143398-A1 | PYRIMIDINYL-PIPERAZINES USEFUL AS D3/D2 RECEPTOR LIGANDS | DRD2, DRD3, AVPR2 | PGK1 3665/4885ACHE 2921/4885TLR9 1561/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.