Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Diethylamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCL8 | P10145 | 7/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.47 |
| ▸ | TTR | P02766 | 3/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.47 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.47 |
| ▸ | UGT1A9 | O60656 | 1/20 | 0.47 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.47 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.47 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.47 |
| ▸ | ALB | P02768 | 1/20 | 0.47 |
| ▸ | UGT1A6 | P19224 | 1/20 | 0.47 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.47 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.47 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.47 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.47 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.47 |
| ▸ | UGT1A7 | Q9HAW7 | 1/20 | 0.47 |
| ▸ | UGT1A10 | Q9HAW8 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL457991 | 0.92 | CXCL8 (0.51) | CXCL8PTGS2TTRPTGS1AKR1B10 | |
| SCHEMBL9618521 | 0.90 | CXCL8 (0.50) | CXCL8PTGS2TTRPTGS1AKR1B10 | |
| SCHEMBL29598223 | 0.90 | CXCL8 (0.50) | CXCL8PTGS2TTRPTGS1AKR1B10 | |
| SCHEMBL9618518 | 0.90 | CXCL8 (0.50) | CXCL8PTGS2TTRPTGS1AKR1B10 | |
| Rubidium SCHEMBL9618522 | 0.90 | CXCL8 (0.50) | CXCL8PTGS2TTRPTGS1AKR1B10 | |
| Potassium SCHEMBL8053105 | 0.90 | CXCL8 (0.50) | CXCL8PTGS2TTRPTGS1AKR1B10 | |
| SCHEMBL8053100 | 0.90 | CXCL8 (0.50) | CXCL8PTGS2TTRPTGS1AKR1B10 | |
| SCHEMBL1961600 | 0.90 | CXCL8 (0.50) | CXCL8PTGS2TTRPTGS1AKR1B10 | |
| SCHEMBL10412874 | 0.83 | CXCL8 (0.50) | CXCL8PTGS2TTRPTGS1AKR1B10 | |
| SCHEMBL10413114 | 0.83 | CXCL8 (0.50) | CXCL8PTGS2TTRPTGS1AKR1B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4999379-A | Transdermal delivery of diclofenac | CIBA-GEIGY CORPORATION (US) | 1991-03-12 | — | — | US | disclosed |
| US-4917886-A | Novel topically administrable pharmaceutical compositions | CIBA-GEIGY CORPORATION (US) | 1990-04-17 | — | — | US | disclosed |