Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 20/20 | 0.49 |
| ▸ | JAK2 | O60674 | 17/20 | 0.49 |
| ▸ | JAK1 | P23458 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL981114 | 1.00 | NTRK1 (0.49) | NTRK1JAK2JAK1 | |
| SCHEMBL19409425 | 0.85 | NTRK1 (0.45) | NTRK1JAK2JAK1 | |
| SCHEMBL988331 | 0.85 | NTRK1 (0.48) | NTRK1JAK2 | |
| SCHEMBL983254 | 0.85 | NTRK1 (0.48) | NTRK1JAK2 | |
| SCHEMBL27095477 | 0.78 | PIK3C3 (0.48) | NTRK1JAK2 | |
| SCHEMBL28173612 | 0.78 | PIK3C3 (0.48) | NTRK1JAK2 | |
| SCHEMBL26968000 | 0.78 | PIK3C3 (0.48) | NTRK1JAK2 | |
| SCHEMBL10241008 | 0.76 | NTRK1 (0.50) | NTRK1JAK2JAK1 | |
| SCHEMBL21097295 | 0.76 | NTRK1 (0.43) | NTRK1 | |
| SCHEMBL28918152 | 0.76 | NTRK1 (0.43) | NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2571883-A1 | MACROCYCLIC COMPOUNDS AS TRK KINASE INHIBITORS | Array Biopharma, Inc. (US) | 2013-03-27 | — | — | EP | disclosed |
| EP-2451812-A1 | SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS TRK KINASE INHIBITORS | Array Biopharma, Inc. (US) | 2012-05-16 | — | — | EP | disclosed |
| WO-2011146336-A1 | MACROCYCLIC COMPOUNDS AS TRK KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2011-11-24 | — | — | WO | disclosed |
| WO-2011006074-A1 | SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS TRK KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2011-01-13 | — | — | WO | disclosed |