Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL988331 | 1.00 | NTRK1 (0.48) | NTRK1JAK2 | |
| SCHEMBL981114 | 0.85 | NTRK1 (0.49) | NTRK1JAK2 | |
| SCHEMBL979031 | 0.85 | NTRK1 (0.49) | NTRK1JAK2 | |
| SCHEMBL28173612 | 0.81 | PIK3C3 (0.48) | NTRK1JAK2 | |
| SCHEMBL26968000 | 0.81 | PIK3C3 (0.48) | NTRK1JAK2 | |
| SCHEMBL27095477 | 0.81 | PIK3C3 (0.48) | NTRK1JAK2 | |
| SCHEMBL28918152 | 0.79 | NTRK1 (0.43) | NTRK1 | |
| SCHEMBL21097295 | 0.79 | NTRK1 (0.43) | NTRK1 | |
| SCHEMBL1082380 | 0.77 | NTRK1 (0.47) | NTRK1JAK2 | |
| SCHEMBL17848931 | 0.77 | NTRK1 (0.45) | NTRK1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2451812-A1 | SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS TRK KINASE INHIBITORS | Array Biopharma, Inc. (US) | 2012-05-16 | — | — | EP | disclosed |
| WO-2011006074-A1 | SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS TRK KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2011-01-13 | — | — | WO | disclosed |