Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 5/20 | 0.53 |
| ▸ | PAM | P19021 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.42 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.42 |
| ▸ | MMP1 | P03956 | 2/20 | 0.41 |
| ▸ | MMP2 | P08253 | 2/20 | 0.41 |
| ▸ | MMP9 | P14780 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 4/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9790488 | 1.00 | MAOB (0.53) | MAOBPAMKMT2AHDAC3HDAC4 | |
| SCHEMBL11551476 | 0.85 | LMNA (0.47) | MAOBKMT2AMMP1MMP2MMP9 | |
| SCHEMBL11553500 | 0.84 | GRIK1 (0.43) | KMT2AHDAC3HDAC4HDAC1HDAC2 | |
| SCHEMBL11552798 | 0.84 | RAB9A (0.43) | KMT2AHDAC1HDAC8HDAC7MMP1 | |
| SCHEMBL973709 | 0.83 | MAOB (0.53) | MAOBPAMKMT2AHDAC3HDAC4 | |
| SCHEMBL973710 | 0.83 | MAOB (0.53) | MAOBPAMKMT2AHDAC3HDAC4 | |
| SCHEMBL11552406 | 0.82 | CYP1A2 (0.49) | MAOBKMT2AMAOAGRIK1GRIK2 | |
| SCHEMBL3125680 | 0.82 | NPSR1 (0.48) | MAOBHDAC3HDAC4HDAC1HDAC2 | |
| SCHEMBL11552409 | 0.82 | CYP1A2 (0.49) | MAOBKMT2AMAOAGRIK1GRIK2 | |
| SCHEMBL3125691 | 0.82 | NPSR1 (0.48) | MAOBHDAC3HDAC4HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4994569-A | Cholecystokinin antagonists | RHONE-POULENC SANTE (FR) | 1991-02-19 | — | — | US | disclosed |
| EP-0000154-B1 | NEW BENZ(F)ISOINDOLINES, THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM | SANDOZ AG (CH) | 1981-07-29 | — | — | EP | disclosed |
| US-4171369-A | ANALGESICS, ANTIDEPRESSANTS | SANDOZ LTD. (CH) | 1979-10-16 | — | — | US | disclosed |
| US-4164583-A | SEDATIVES, TRANQUILIZERS | SANDOZ LTD. (CH) | 1979-08-14 | — | — | US | disclosed |
| EP-0000154-A1 | New benz(f)isoindolines, their preparation and medicaments containing them | SANDOZ AG (CH) | 1979-01-10 | — | — | EP | disclosed |