Sugi Predict

Sugi Predict / Compounds / SCHEMBL979235

SCHEMBL979235

SCHEMBL979235

Nc1nnc(-c2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(N)n1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ADORA2A P29274 11/20 0.52
▸ ADORA1 P30542 10/20 0.52
▸ CSNK1A1 P48729 1/20 0.50
▸ CLK4 Q9HAZ1 1/20 0.50
▸ IKBKB O14920 1/20 0.41
▸ CYP2D6 P10635 2/20 0.37
▸ CYP1A2 P05177 1/20 0.37
▸ CYP3A4 P08684 1/20 0.37
▸ CYP2C9 P11712 1/20 0.37
▸ CYP2C19 P33261 1/20 0.37
▸ ADORA2B P29275 1/20 0.36
▸ RORC P51449 1/20 0.36
▸ RORB Q92753 1/20 0.36
▸ MAOA P21397 1/20 0.36
▸ MAPK1 P28482 1/20 0.36
▸ ADRA1A P35348 1/20 0.36
▸ SCN4A P35499 1/20 0.36
▸ BLM P54132 1/20 0.36
▸ PMP22 Q01453 1/20 0.36
▸ PDE3A Q14432 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29870155 1.00 ADORA2A (0.52) ADORA2AADORA1CSNK1A1CLK4IKBKB
SCHEMBL975901 0.89 ADORA2A (0.67) ADORA2AADORA1CSNK1A1CLK4IKBKB
SCHEMBL13481022 0.83 ADORA2A (0.74) ADORA2AADORA1CSNK1A1CLK4IKBKB
SCHEMBL978400 0.82 KDM4E (0.53) ADORA2AADORA1CSNK1A1CLK4CYP2D6
SCHEMBL2329483 0.79 ADORA2A (0.81) ADORA2AADORA1ADORA2B
SCHEMBL977343 0.74 MAPT (0.51) ADORA2AADORA1CSNK1A1CLK4SCN5A
SCHEMBL12948664 0.74 ADORA2A (0.47) ADORA2AADORA1CSNK1A1CLK4CYP2D6
SCHEMBL978559 0.73 SCN9A (0.46) ADORA2AADORA1CSNK1A1CLK4CYP2D6
SCHEMBL977678 0.72 ADORA2A (0.46) ADORA2AADORA1CSNK1A1CLK4CYP2D6
SCHEMBL29870051 0.72 ADORA2A (0.46) ADORA2AADORA1CSNK1A1CLK4CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107921046-B Triazine derivatives as interferon-gamma inhibitors 格林威治大学 2022-10-14 — — CN claimed
EP-3307273-B1 TRIAZINE DERIVATIVES AS INTERFERON-GAMMA INHIBITORS UNIV GREENWICH (GB) 2020-12-09 — — EP claimed
US-10576086-B2 Triazine derivatives as interferon-gamma inhibitors UNIVERSITY OF GREENWICH (GB) 2020-03-03 — — US claimed
US-20180169105-A1 TRIAZINE DERIVATIVES AS INTERFERON-GAMMA INHIBITORS UNIVERSITY OF GREENWICH (GB) 2018-06-21 — — US claimed
EP-3307273-A1 TRIAZINE DERIVATIVES AS INTERFERON-GAMMA INHIBITORS University of Greenwich (GB) 2018-04-18 — — EP claimed
US-9862691-B2 Cyclic triazo and diazo sodium channel blockers UNIVERSITY OF GREENWICH (GB) 2018-01-09 — — US claimed
WO-2016198878-A1 TRIAZINE DERIVATIVES AS INTERFERON-GAMMA INHIBITORS UNIVERSITY OF GREENWICH (GB) 2016-12-15 — — WO claimed
US-20160311784-A1 CYCLIC TRIAZO AND DIAZO SODIUM CHANNEL BLOCKERS UNIVERSITY OF GREENWICH (GB) 2016-10-27 — — US claimed
EP-3002280-A1 CYCLIC TRIAZO AND DIAZO SODIUM CHANNEL BLOCKERS University of Greenwich (GB) 2016-04-06 — — EP claimed
US-20140155403-A1 CYCLIC TRIAZO AND DIAZO SODIUM CHANNEL BLOCKERS UNIVERSITY OF GREENWICH (GB) 2014-06-05 — — US claimed
EP-3002280-B1 CYCLIC TRIAZO AND DIAZO SODIUM CHANNEL BLOCKERS UNIV GREENWICH (GB) 2023-05-24 — — EP disclosed
CN-115737651-A Triazine derivatives as interferon-gamma inhibitors 格林威治大学 2023-03-07 — — CN disclosed
CN-107921046-B Triazine derivatives as interferon-gamma inhibitors 格林威治大学 2022-10-14 — — CN disclosed
EP-3307273-B1 TRIAZINE DERIVATIVES AS INTERFERON-GAMMA INHIBITORS UNIV GREENWICH (GB) 2020-12-09 — — EP disclosed
US-10576086-B2 Triazine derivatives as interferon-gamma inhibitors UNIVERSITY OF GREENWICH (GB) 2020-03-03 — — US disclosed
US-20140155403-A1 CYCLIC TRIAZO AND DIAZO SODIUM CHANNEL BLOCKERS UNIVERSITY OF GREENWICH (GB) 2014-06-05 — — US disclosed
CN-101918378-B Cyclic azide and sodium diazoxide channel blockers UNIV GREENWICH 2013-12-04 — — CN disclosed
US-20110009413-A1 CYCLIC TRIAZO AND DIAZO SODIUM CHANNEL BLOCKERS UNIVERSITY OF GREENWICH (GB) 2011-01-13 — — US disclosed
EP-2229371-A1 CYCLIC TRIAZO AND DIAZO SODIUM CHANNEL BLOCKERS University of Greenwich (GB) 2010-09-22 — — EP disclosed
WO-2009090431-A1 CYCLIC TRIAZO AND DIAZO SODIUM CHANNEL BLOCKERS UNIVERSITY OF GREENWICH (GB) 2009-07-23 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140155403-A1 CYCLIC TRIAZO AND DIAZO SODIUM CHANNEL BLOCKERS SCN1A, SCN1B, SCN3A ADORA2A 396/4885ADORA1 243/4885CSNK1A1 719/4885
US-20110009413-A1 CYCLIC TRIAZO AND DIAZO SODIUM CHANNEL BLOCKERS CACNA1E, SCN2B, SCN3A ADORA2A 806/4885ADORA1 775/4885CSNK1A1 4578/4885
US-10576086-B2 Triazine derivatives as interferon-gamma inhibitors IFNG, IFNAR1, IRF3 ADORA2A 3674/4885ADORA1 3081/4885CSNK1A1 599/4885
US-20180169105-A1 TRIAZINE DERIVATIVES AS INTERFERON-GAMMA INHIBITORS IFNG, IFNAR1, IRF3 ADORA2A 3674/4885ADORA1 3081/4885CSNK1A1 599/4885
US-20160311784-A1 CYCLIC TRIAZO AND DIAZO SODIUM CHANNEL BLOCKERS SCN1A, SCN1B, SCN3A ADORA2A 373/4885ADORA1 217/4885CSNK1A1 802/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.