Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GART | P22102 | 17/20 | 0.73 |
| ▸ | ATIC | P31939 | 2/20 | 0.56 |
| ▸ | DHFR | P00374 | 1/20 | 0.51 |
| ▸ | FOLR2 | P14207 | 1/20 | 0.50 |
| ▸ | FOLR1 | P15328 | 1/20 | 0.50 |
| ▸ | SLC19A1 | P41440 | 1/20 | 0.50 |
| ▸ | SLC46A1 | Q96NT5 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9794846 | 1.00 | GART (0.73) | GARTATICDHFRFOLR2FOLR1 | |
| SCHEMBL9794852 | 0.88 | GART (0.72) | GARTATICFOLR2FOLR1SLC46A1 | |
| SCHEMBL9794858 | 0.88 | GART (0.72) | GARTATICFOLR2FOLR1SLC46A1 | |
| SCHEMBL9794911 | 0.84 | GART (1.00) | GARTATICFOLR2FOLR1SLC19A1 | |
| SCHEMBL10421274 | 0.80 | GART (0.50) | GARTATICDHFR | |
| SCHEMBL10421275 | 0.80 | GART (0.50) | GARTATICDHFR | |
| SCHEMBL7615333 | 0.80 | GART (0.57) | GARTDHFRFOLR2FOLR1SLC46A1 | |
| SCHEMBL9794864 | 0.80 | GART (0.59) | GARTATICDHFR | |
| SCHEMBL7607120 | 0.79 | GART (0.71) | GARTATICFOLR1 | |
| SCHEMBL7609761 | 0.79 | GART (0.70) | GARTATICDHFRFOLR2FOLR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0409382-A1 | Glutamic acid derivatives | THE WELLCOME FOUNDATION LIMITED (GB) | 1991-01-23 | — | — | EP | disclosed |
| US-4971973-A | Antitumor agents from polyglutamic acid modified with n- 4- 3-(2,4-diamino-1,6-dihydro-6-oxo-5-pyrimidinyl!propoxyl!benzoyl -glutamic acid | BURROUGHS WELLCOME CO. (US) | 1990-11-20 | — | — | US | disclosed |