Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GART | P22102 | 4/20 | 0.59 |
| ▸ | DHFR | P00374 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | ATIC | P31939 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9794867 | 0.86 | GART (0.66) | GARTDHFRALDH1A1KMT2AATIC | |
| SCHEMBL9794872 | 0.85 | GART (0.58) | GARTLMNARAB9AALDH1A1MEN1 | |
| SCHEMBL9794846 | 0.80 | GART (0.73) | GARTDHFRATIC | |
| SCHEMBL9794843 | 0.80 | GART (0.73) | GARTDHFRATIC | |
| SCHEMBL9794911 | 0.74 | GART (1.00) | GARTATIC | |
| SCHEMBL5166263 | 0.73 | TDP1 (0.66) | LMNATBXAS1TDP1L3MBTL1ALDH1A1 | |
| SCHEMBL6701399 | 0.73 | TDP1 (0.74) | LMNARAB9AHSD17B10TBXAS1TDP1 | |
| SCHEMBL9798438 | 0.72 | L3MBTL1 (0.61) | DHFRLMNATBXAS1TDP1L3MBTL1 | |
| Hydrochloric Acid SCHEMBL6983034 | 0.71 | TDP1 (0.59) | DHFRLMNATBXAS1TDP1L3MBTL1 | |
| SCHEMBL4247628 | 0.71 | TDP1 (0.62) | LMNATBXAS1TDP1L3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0409382-A1 | Glutamic acid derivatives | THE WELLCOME FOUNDATION LIMITED (GB) | 1991-01-23 | — | — | EP | disclosed |
| WO-1990014340-A1 | GLUTAMIC ACID DERIVATIVES | THE WELLCOME FOUNDATION LIMITED (GB) | 1990-11-29 | — | — | WO | disclosed |
| US-4971973-A | Antitumor agents from polyglutamic acid modified with n- 4- 3-(2,4-diamino-1,6-dihydro-6-oxo-5-pyrimidinyl!propoxyl!benzoyl -glutamic acid | BURROUGHS WELLCOME CO. (US) | 1990-11-20 | — | — | US | disclosed |