Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GART | P22102 | 20/20 | 1.00 |
| ▸ | ATIC | P31939 | 3/20 | 0.77 |
| ▸ | FOLR2 | P14207 | 1/20 | 0.68 |
| ▸ | FOLR1 | P15328 | 1/20 | 0.68 |
| ▸ | SLC46A1 | Q96NT5 | 1/20 | 0.68 |
| ▸ | SHMT1 | P34896 | 1/20 | 0.66 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dideazaacyclotetrahydrofolic Acid SCHEMBL14469101 | 0.87 | GART (1.00) | GARTATICFOLR2FOLR1SLC46A1 | |
| SCHEMBL5491752 | 0.87 | GART (0.82) | GARTATIC | |
| SCHEMBL5673952 | 0.87 | GART (0.82) | GARTATIC | |
| SCHEMBL9794911 | 0.86 | GART (1.00) | GARTATICFOLR2FOLR1SLC46A1 | |
| SCHEMBL7615527 | 0.86 | GART (0.81) | GARTATICFOLR2FOLR1SLC46A1 | |
| SCHEMBL9688062 | 0.85 | GART (0.79) | GARTATIC | |
| SCHEMBL18160919 | 0.84 | GART (1.00) | GARTFOLR2FOLR1SLC46A1 | |
| SCHEMBL10419882 | 0.84 | GART (0.80) | GARTATIC | |
| SCHEMBL7606988 | 0.84 | GART (1.00) | GARTATICFOLR2FOLR1SLC46A1 | |
| SCHEMBL9794852 | 0.84 | GART (0.72) | GARTATICFOLR2FOLR1SLC46A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0409382-A1 | Glutamic acid derivatives | THE WELLCOME FOUNDATION LIMITED (GB) | 1991-01-23 | — | — | EP | claimed |
| WO-1990014340-A1 | GLUTAMIC ACID DERIVATIVES | THE WELLCOME FOUNDATION LIMITED (GB) | 1990-11-29 | — | — | WO | claimed |
| US-4921836-A | ANTITUMOR AGENTS | BURROUGHS WELLCOME CO. (US) | 1990-05-01 | — | — | US | claimed |
| EP-0409382-A1 | Glutamic acid derivatives | THE WELLCOME FOUNDATION LIMITED (GB) | 1991-01-23 | — | — | EP | disclosed |
| US-4921836-A | ANTITUMOR AGENTS | BURROUGHS WELLCOME CO. (US) | 1990-05-01 | — | — | US | disclosed |