Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.37 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | PAOX | Q6QHF9 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | TERT | O14746 | 2/20 | 0.33 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4505848 | 0.84 | SMN1; SMN2 (0.52) | ALDH1A1TP53SMN1; SMN2GABRR1HPGD | |
| SCHEMBL20581925 | 0.82 | ALDH1A1 (0.50) | ALDH1A1TP53SMN1; SMN2HPGDKMT2A | |
| SCHEMBL20581926 | 0.82 | ALDH1A1 (0.50) | ALDH1A1TP53SMN1; SMN2HPGDKMT2A | |
| SCHEMBL22929128 | 0.81 | TP53 (0.37) | ALDH1A1TP53SMN1; SMN2GABRR1PDK2 | |
| SCHEMBL21888407 | 0.81 | GABRR1 (0.50) | ALDH1A1TP53SMN1; SMN2GABRR1HPGD | |
| SCHEMBL5907647 | 0.80 | ALDH1A1 (0.48) | ALDH1A1TP53SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL14984047 | 0.80 | ALDH1A1 (0.50) | ALDH1A1TP53SMN1; SMN2HPGDKMT2A | |
| SCHEMBL3831548 | 0.80 | ALDH1A1 (0.48) | ALDH1A1TP53SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL20670296 | 0.79 | TP53 (0.36) | ALDH1A1TP53SMN1; SMN2GABRR1PDK2 | |
| SCHEMBL10594782 | 0.79 | ALDH1A1 (0.77) | ALDH1A1GABRR1PDK2HPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5037849-A | For treatment of heart and circulatory diseases | BOEHRINGER MANNHEIM GMBH (DE) | 1991-08-06 | — | — | US | disclosed |
| EP-0200915-B1 | AMINOPROPANOL DERIVATIVES, PROCESS FOR THEIR PREPARATION, THEIR USE AND MEDICINES CONTAINING THEM | Roche Diagnostics GmbH (DE) | 1989-09-27 | — | — | EP | disclosed |
| US-4863949-A | CARDIOVASCULAR DISORDER TREATMENT | BOEHRINGER MANNHEIM GMBH (DE) | 1989-09-05 | — | — | US | disclosed |
| EP-0200915-A1 | Aminopropanol derivatives, process for their preparation, their use and medicines containing them | Roche Diagnostics GmbH (DE) | 1986-11-12 | — | — | EP | disclosed |