Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 6/20 | 0.56 |
| ▸ | CDC7 | O00311 | 6/20 | 0.56 |
| ▸ | DBF4 | Q9UBU7 | 6/20 | 0.56 |
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.50 |
| ▸ | CRHBP | P24387 | 1/20 | 0.50 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5647609 | 0.87 | CDC7 (0.54) | TRPM8CDC7DBF4MAPTKDM4E | |
| SCHEMBL9795563 | 0.87 | TRPM8 (0.54) | TRPM8CDC7DBF4MAPTKDM4E | |
| SCHEMBL5553648 | 0.84 | ALDH1A1 (0.58) | CDC7DBF4MAPTKDM4EMEN1 | |
| SCHEMBL1194336 | 0.82 | TRPM8 (0.59) | TRPM8CDC7DBF4MAPTKDM4E | |
| SCHEMBL29030799 | 0.81 | ALDH1A1 (0.47) | TRPM8CDC7DBF4MAPTKDM4E | |
| SCHEMBL5119774 | 0.79 | CDC7 (0.71) | TRPM8CDC7DBF4MAPTKDM4E | |
| SCHEMBL3921966 | 0.79 | ALDH1A1 (0.71) | TRPM8CDC7DBF4MAPTKDM4E | |
| SCHEMBL7237097 | 0.79 | ALDH1A1 (0.46) | TRPM8CDC7DBF4MAPTKDM4E | |
| SCHEMBL7620013 | 0.79 | ALDH1A1 (0.49) | TRPM8CDC7DBF4MAPTKDM4E | |
| SCHEMBL8507216 | 0.78 | ALDH1A1 (0.51) | TRPM8MAPTKDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023074847-A1 | NOVEL SPIRO COMPOUND | 田辺三菱製薬株式会社 | 2023-05-04 | — | — | WO | disclosed |
| US-7179827-B2 | Thiazoles and methods of their use | LEXICON GENETICS INCORPORATED (US) | 2007-02-20 | — | — | US | disclosed |
| US-5057142-A | Herbicidal thiazolecarboxamide derivatives | BAYER AKTIENGESELLSCHAFT (DE) | 1991-10-15 | — | — | US | disclosed |
| EP-0422470-A2 | Thiazolcarboxylic acid amide derivatives | BAYER AG (DE) | 1991-04-17 | — | — | EP | disclosed |