Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.60 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | RAD52 | P43351 | 1/20 | 0.50 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | KCNK13 | Q9HB14 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1170261 | 0.83 | TLR8 (0.72) | RPS6KA5TLR8POLBNUDT1BACE1 | |
| SCHEMBL10641373 | 0.81 | KDM4E (0.64) | HTTCYP1A2RPS6KA5KDM4EMAPT | |
| SCHEMBL12598268 | 0.81 | TLR8 (0.70) | HTTCYP1A2CYP2D6RPS6KA5KDM4E | |
| SCHEMBL21310933 | 0.80 | RPS6KA5 (0.44) | HTTCYP1A2CYP2D6RPS6KA5TLR8 | |
| SCHEMBL14521693 | 0.80 | CYP1A2 (0.55) | HTTCYP1A2CYP2D6KDM4ERAD52 | |
| SCHEMBL6622952 | 0.78 | HTT (0.57) | HTTCYP1A2CYP2D6RPS6KA5KDM4E | |
| SCHEMBL2857719 | 0.77 | MEN1 (0.44) | RPS6KA5KDM4EMAPTTLR8ALDH1A1 | |
| SCHEMBL12658348 | 0.77 | SOS1 (0.56) | HTTALDH1A1POLBKMT2AKCNK13 | |
| SCHEMBL10642457 | 0.76 | RPS6KA5 (0.49) | HTTCYP1A2RPS6KA5KDM4EMAPT | |
| SCHEMBL1992429 | 0.75 | CYP1A2 (1.00) | HTTCYP1A2CYP2D6RPS6KA5KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9636345-B2 | Benzimidazole derivatives useful TRPM8 channel modulators | JANSSEN PHARMACEUTICA NV (BE) | 2017-05-02 | — | — | US | disclosed |
| US-20150150882-A1 | BENZIMIDAZOLE DERIVATIVES USEFUL TRPM8 CHANNEL MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2015-06-04 | — | — | US | disclosed |
| US-8981113-B2 | Benzimidazole derivatives useful as TRPM8 channel modulators | JANSSEN PHARMACEUTICA NV (BE) | 2015-03-17 | — | — | US | disclosed |
| US-20130245085-A1 | BENZIMIDAZOLE DERIVATIVES USEFUL AS TRPM8 CHANNEL MODULATORS | JANSSEN PHARMACEUTICA, NV (BE) | 2013-09-19 | — | — | US | disclosed |
| EP-2440294-B1 | BENZIMIDAZOLE DERIVATIVES USEFUL AS TRPM8 CHANNEL MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2013-07-24 | — | — | EP | disclosed |
| EP-2440295-B1 | BENZIMIDAZOLE DERIVATIVES USEFUL AS TRPM8 CHANNEL MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2013-07-24 | — | — | EP | disclosed |
| US-8450497-B2 | Benzimidazole derivatives useful as TRPM8 channel modulators | JANSSEN PHARMACEUTICA, NV (BE) | 2013-05-28 | — | — | US | disclosed |
| US-8242157-B2 | Benzimidazole derivatives useful as TRPM8 channel modulators | JANSSEN PHARMACEUTICA NV (BE) | 2012-08-14 | — | — | US | disclosed |
| EP-2440294-A1 | BENZIMIDAZOLE DERIVATIVES USEFUL AS TRPM8 CHANNEL MODULATORS | Janssen Pharmaceutica, N.V. (BE) | 2012-04-18 | — | — | EP | disclosed |
| EP-2440295-A1 | BENZIMIDAZOLE DERIVATIVES USEFUL AS TRPM8 CHANNEL MODULATORS | Janssen Pharmaceutica, N.V. (BE) | 2012-04-18 | — | — | EP | disclosed |
| US-20110003801-A1 | BENZIMIDAZOLE DERIVATIVES USEFUL AS TRPM8 CHANNEL MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2011-01-06 | — | — | US | disclosed |
| US-20110003800-A1 | BENZIMIDAZOLE DERIVATIVES USEFUL AS TRPM8 CHANNEL MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2011-01-06 | — | — | US | disclosed |
| WO-2010144680-A1 | BENZIMIDAZOLE DERIVATIVES USEFUL AS TRPM8 CHANNEL MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2010-12-16 | — | — | WO | disclosed |
| WO-2010144679-A1 | BENZIMIDAZOLE DERIVATIVES USEFUL AS TRPM8 CHANNEL MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2010-12-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110003800-A1 | BENZIMIDAZOLE DERIVATIVES USEFUL AS TRPM8 CHANNEL MODULATORS | TRPM8, TRPM4, TRPM6 | HTT 3961/4885CYP1A2 2842/4885CYP2D6 1847/4885 |
| US-20130245085-A1 | BENZIMIDAZOLE DERIVATIVES USEFUL AS TRPM8 CHANNEL MODULATORS | TRPM8, TRPM4, TRPM6 | HTT 3961/4885CYP1A2 2842/4885CYP2D6 1847/4885 |
| US-20150150882-A1 | BENZIMIDAZOLE DERIVATIVES USEFUL TRPM8 CHANNEL MODULATORS | TRPM8, TRPM4, TRPM6 | HTT 3738/4885CYP1A2 3457/4885CYP2D6 2266/4885 |
| US-20110003801-A1 | BENZIMIDAZOLE DERIVATIVES USEFUL AS TRPM8 CHANNEL MODULATORS | TRPM8, TRPM4, TRPM6 | HTT 3961/4885CYP1A2 2842/4885CYP2D6 1847/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.