Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.54 |
| ▸ | RELA | Q04206 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | PPARG | P37231 | 1/20 | 0.49 |
| ▸ | PPARD | Q03181 | 1/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.48 |
| ▸ | HRH1 | P35367 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4331486 | 0.95 | SMN1; SMN2 (0.56) | SMN1; SMN2KDM4EPOLBNPC1NFKB1 | |
| Ethane SCHEMBL4326322 | 0.92 | POLB (0.55) | SMN1; SMN2KDM4EPOLBNPC1NFKB1 | |
| SCHEMBL29825051 | 0.91 | SMN1; SMN2 (0.56) | SMN1; SMN2KDM4EPOLBNPC1NFKB1 | |
| SCHEMBL15625501 | 0.84 | KDM4E (0.60) | SMN1; SMN2KDM4EPOLBNPC1NFKB1 | |
| SCHEMBL9720056 | 0.83 | PPARG (0.64) | SMN1; SMN2KDM4EPOLBNPC1NFKB1 | |
| SCHEMBL22692759 | 0.81 | KDM4E (0.57) | SMN1; SMN2KDM4EPOLBNPC1NFKB1 | |
| SCHEMBL27829035 | 0.81 | SMN1; SMN2 (0.60) | SMN1; SMN2KDM4EPOLBNPC1NFKB1 | |
| SCHEMBL23222346 | 0.80 | SMN1; SMN2 (0.56) | SMN1; SMN2KDM4EPOLBNPC1NFKB1 | |
| SCHEMBL7214609 | 0.80 | SMN1; SMN2 (0.56) | SMN1; SMN2KDM4EPOLBNPC1NFKB1 | |
| SCHEMBL3150833 | 0.80 | SMN1; SMN2 (0.56) | SMN1; SMN2KDM4EPOLBNPC1NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5036070-A | Treatment of nervous system disorders, schizophrenia, anxiety, paranoia | AMERICAN HOME PRODUCTS CORPORATION (US) | 1991-07-30 | — | — | US | disclosed |
| US-4339580-A | TRANQUILIZERS, SEDATIVES | MITSUBISHI CHEMICAL INDUSTRIES, LIMITED (JP) | 1982-07-13 | — | — | US | disclosed |
| EP-0021368-B1 | PIPERAZINYLALKOXYINDANES AND ACID ADDITION SALTS THEREOF | MITSUBISHI KASEI CORPORATION (JP) | 1982-05-19 | — | — | EP | disclosed |
| EP-0021368-A1 | Piperazinylalkoxyindanes and acid addition salts thereof | MITSUBISHI KASEI CORPORATION (JP) | 1981-01-07 | — | — | EP | disclosed |