Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.55 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.55 |
| ▸ | RELA | Q04206 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | PPARG | P37231 | 1/20 | 0.50 |
| ▸ | PPARD | Q03181 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | RXRA | P19793 | 2/20 | 0.48 |
| ▸ | RXRB | P28702 | 2/20 | 0.48 |
| ▸ | RXRG | P48443 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9720056 | 0.84 | PPARG (0.64) | SMN1; SMN2NPC1RAB9ANFKB1NFKB2 | |
| SCHEMBL15625501 | 0.81 | KDM4E (0.60) | SMN1; SMN2NPC1RAB9ANFKB1NFKB2 | |
| SCHEMBL29825051 | 0.81 | SMN1; SMN2 (0.56) | SMN1; SMN2NPC1RAB9ANFKB1NFKB2 | |
| SCHEMBL23222346 | 0.81 | SMN1; SMN2 (0.56) | SMN1; SMN2NPC1RAB9ANFKB1NFKB2 | |
| SCHEMBL3150833 | 0.81 | SMN1; SMN2 (0.56) | SMN1; SMN2NPC1RAB9ANFKB1NFKB2 | |
| SCHEMBL6172712 | 0.80 | MAOB (0.67) | HRH3 | |
| SCHEMBL9796002 | 0.80 | SMN1; SMN2 (0.57) | SMN1; SMN2NPC1RAB9ANFKB1NFKB2 | |
| SCHEMBL9720055 | 0.79 | ALOX15 (0.59) | SMN1; SMN2NPC1RAB9ANFKB1NFKB2 | |
| SCHEMBL4331486 | 0.79 | SMN1; SMN2 (0.56) | SMN1; SMN2NPC1RAB9ANFKB1NFKB2 | |
| SCHEMBL22692759 | 0.79 | KDM4E (0.57) | SMN1; SMN2NPC1RAB9ANFKB1NFKB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6610712-B2 | Treating serotonin-related central nervous system disorders | WYETH | 2003-08-26 | — | — | US | disclosed |
| US-20020091141-A1 | Aryloxy piperidinyl derivatives for the treatment of depression | AMERICAN HOME PRODUCTS CORPORATION (US) | 2002-07-11 | — | — | US | disclosed |
| WO-2002048105-A2 | ARYLOXY PIPERIDINYL DERIVATIVES FOR THE TREATMENT OF DEPRESSION | WYETH (US) | 2002-06-20 | — | — | WO | disclosed |
| US-6291683-B1 | AS ANTIDEPRESSANTS | AMERICAN HOME PRODUCTS CORP | 2001-09-18 | — | — | US | disclosed |
| EP-1070050-A1 | N-ARYLOXYETHYL-INDOLY-ALKYLAMINES FOR THE TREATMENT OF DEPRESSION (5-HT1A RECEPTOR ACTIVE AGENTS) | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-01-24 | — | — | EP | disclosed |
| US-6121307-A | SIDE EFFECT REDUCTION; ADMINISTERING TO TREAT DEPRESSION | AMERICAN HOME PRODUCTS CORP. (US) | 2000-09-19 | — | — | US | disclosed |
| WO-1999051575-A1 | N-ARYLOXYETHYL-INDOLY-ALKYLAMINES FOR THE TREATMENT OF DEPRESSION (5-HT1A RECEPTOR ACTIVE AGENTS) | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-10-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020091141-A1 | Aryloxy piperidinyl derivatives for the treatment of depression | HTR2C, HTR1A, OPRD1 | SMN1; SMN2 448/4885NPC1 291/4885RAB9A 2865/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.