Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | GLA | P06280 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | GRIK1 | P39086 | 3/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1321725 | 0.85 | KDM4E (0.63) | KDM4EALDH1A1GLAGAASMN1; SMN2 | |
| SCHEMBL9796443 | 0.85 | ALDH1A1 (0.71) | KDM4EALDH1A1GLAGAASMN1; SMN2 | |
| SCHEMBL3811074 | 0.83 | KDM4E (0.54) | KDM4EALDH1A1GLAGAASMN1; SMN2 | |
| SCHEMBL7169725 | 0.83 | KDM4E (0.74) | KDM4EALDH1A1GLAGAASMN1; SMN2 | |
| SCHEMBL5875315 | 0.81 | ABL1 (0.62) | KDM4EALDH1A1GLAGAASMN1; SMN2 | |
| SCHEMBL1975830 | 0.81 | KDM4E (0.55) | KDM4EALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL18534737 | 0.81 | KDM4E (0.47) | KDM4EALDH1A1GLAGAASMN1; SMN2 | |
| SCHEMBL23486513 | 0.80 | KDM4E (0.43) | KDM4EALDH1A1GLAGAASMN1; SMN2 | |
| SCHEMBL27731721 | 0.80 | ALDH1A1 (0.58) | KDM4EALDH1A1GLAGAASMN1; SMN2 | |
| SCHEMBL3811178 | 0.80 | ALDH1A1 (0.51) | KDM4EALDH1A1GLAGAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5045539-A | 1H-indolo[3,2-c]quinoline-derivatives, compositions containing same, useful for treating pain, psychosis or convulsions | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1991-09-03 | — | — | US | disclosed |
| US-5006531-A | 5,6-dihydro(1H-indolo(3,2-C)quinoline-6,4'-piperidines) and related compounds which are useful for treating pain, psychosis or convulsions | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1991-04-09 | — | — | US | disclosed |
| US-4997840-A | Quinolone sulphonates having antihypertensive activity | THE BOOTS COMPANY, PLC (GB) | 1991-03-05 | — | — | US | disclosed |
| EP-0407898-A1 | 5,6-dihydro(1H-indolo(3,2-c)quinoline-6,4-piperidines)and related compounds, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-01-16 | — | — | EP | disclosed |
| EP-0330340-A1 | Therapeutic agents | The Boots Company PLC (GB) | 1989-08-30 | — | — | EP | disclosed |
| WO-1989007593-A1 | THERAPEUTIC AGENTS | THE BOOTS COMPANY PLC (GB) | 1989-08-24 | — | — | WO | disclosed |