Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | CES2 | O00748 | 3/20 | 0.44 |
| ▸ | CES1 | P23141 | 3/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | ALB | P02768 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29785235 | 0.85 | ALB (0.55) | GAAKMT2ASMN1; SMN2CES2CES1 | |
| SCHEMBL20303914 | 0.85 | ALB (0.55) | GAAKMT2ASMN1; SMN2CES2CES1 | |
| SCHEMBL20355746 | 0.83 | GAA (0.47) | GAAKMT2ACES2CES1BCHE | |
| SCHEMBL28770538 | 0.80 | GAA (0.44) | GAAKMT2ASMN1; SMN2CES2CES1 | |
| SCHEMBL9941271 | 0.80 | KMT2A (0.60) | KMT2ASMN1; SMN2MEN1TDP1ALDH1A1 | |
| SCHEMBL23203561 | 0.78 | POLB (0.44) | KMT2ACES2CES1MEN1ALDH1A1 | |
| SCHEMBL11111854 | 0.78 | POLB (0.47) | GAAKMT2ASMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL4607670 | 0.78 | L3MBTL1 (0.47) | GAAKMT2ASMN1; SMN2CES2CES1 | |
| SCHEMBL22502933 | 0.78 | TRPA1 (0.48) | GAAKMT2ASMN1; SMN2CES2CES1 | |
| SCHEMBL4649815 | 0.77 | KDM4E (0.35) | GAAKMT2ASMN1; SMN2ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4997840-A | Quinolone sulphonates having antihypertensive activity | THE BOOTS COMPANY, PLC (GB) | 1991-03-05 | — | — | US | disclosed |
| EP-0330340-A1 | Therapeutic agents | The Boots Company PLC (GB) | 1989-08-30 | — | — | EP | disclosed |
| WO-1989007593-A1 | THERAPEUTIC AGENTS | THE BOOTS COMPANY PLC (GB) | 1989-08-24 | — | — | WO | disclosed |