Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | AHR | P35869 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | TAS1R3 | Q7RTX0 | 3/20 | 0.39 |
| ▸ | TAS1R1 | Q7RTX1 | 3/20 | 0.39 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13503862 | 0.86 | ALDH1A1 (0.48) | POLBNPC1AHRALDH1A1LMNA | |
| SCHEMBL19308888 | 0.79 | MEN1 (0.51) | POLBNPC1AHRALDH1A1HTT | |
| SCHEMBL7094825 | 0.79 | POLB (0.46) | POLBNPC1AHRALDH1A1LMNA | |
| SCHEMBL23034212 | 0.79 | POLB (0.49) | POLBNPC1AHRALDH1A1LMNA | |
| SCHEMBL22537184 | 0.79 | TAS1R3 (0.39) | ALDH1A1KMT2AMEN1TSHRTAS1R3 | |
| SCHEMBL1911939 | 0.77 | NQO2 (0.50) | ALDH1A1LMNASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL11198967 | 0.77 | POLB (0.50) | POLBNPC1AHRALDH1A1LMNA | |
| SCHEMBL22537400 | 0.76 | TAS1R3 (0.43) | ALDH1A1SMN1; SMN2TAS1R3TAS1R1MAPT | |
| SCHEMBL13503616 | 0.76 | ALDH1A1 (0.43) | POLBNPC1AHRALDH1A1LMNA | |
| SCHEMBL850628 | 0.75 | ALDH1A1 (0.46) | POLBNPC1ALDH1A1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4997840-A | Quinolone sulphonates having antihypertensive activity | THE BOOTS COMPANY, PLC (GB) | 1991-03-05 | — | — | US | disclosed |
| WO-1989007593-A1 | THERAPEUTIC AGENTS | THE BOOTS COMPANY PLC (GB) | 1989-08-24 | — | — | WO | disclosed |