Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | GSK3B | P49841 | 4/20 | 0.41 |
| ▸ | PRKCA | P17252 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9796274 | 0.89 | NTRK1 (0.41) | KMT2AKDM4EGSK3BMAPTMAPK8 | |
| SCHEMBL9796513 | 0.83 | ALDH1A1 (0.48) | KMT2AKDM4EGSK3BMAPTCDK2 | |
| SCHEMBL6050601 | 0.80 | ALDH1A1 (0.45) | KMT2AKDM4ECDK2MEN1ALDH1A1 | |
| SCHEMBL9796526 | 0.77 | TP53 (0.48) | KMT2ANPC1POLBRXFP1TP53 | |
| SCHEMBL9796630 | 0.77 | TP53 (0.41) | KMT2AKDM4EMAPTMEN1POLB | |
| SCHEMBL9796325 | 0.76 | TP53 (0.41) | KMT2AKDM4EGSK3BPRKCAMEN1 | |
| SCHEMBL9796539 | 0.75 | CREBBP (0.40) | KMT2AKDM4EMEN1ALDH1A1HPGD | |
| SCHEMBL9796452 | 0.75 | ATM (0.44) | KMT2AKDM4EGSK3BPRKCAMAPK8 | |
| SCHEMBL9796185 | 0.74 | KDM4E (0.33) | KMT2AKDM4EMAPTMEN1ALDH1A1 | |
| SCHEMBL9796276 | 0.74 | ALDH1A1 (0.51) | GSK3BPRKCAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4997840-A | Quinolone sulphonates having antihypertensive activity | THE BOOTS COMPANY, PLC (GB) | 1991-03-05 | — | — | US | disclosed |
| EP-0330340-A1 | Therapeutic agents | The Boots Company PLC (GB) | 1989-08-30 | — | — | EP | disclosed |
| WO-1989007593-A1 | THERAPEUTIC AGENTS | THE BOOTS COMPANY PLC (GB) | 1989-08-24 | — | — | WO | disclosed |