Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | MAT2A | P31153 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | ALPL | P05186 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9796512 | 0.89 | KMT2A (0.46) | GSK3BKMT2AKDM4EMAPTMAPK8 | |
| SCHEMBL9796325 | 0.84 | TP53 (0.41) | NTRK1LMNATHRBGSK3BKMT2A | |
| SCHEMBL9796539 | 0.83 | CREBBP (0.40) | LMNAKMT2AKDM4E | |
| SCHEMBL9796452 | 0.83 | ATM (0.44) | GSK3BKMT2AKDM4EMAPK8CYP1A2 | |
| SCHEMBL9796276 | 0.82 | ALDH1A1 (0.51) | NTRK1GSK3B | |
| SCHEMBL9796185 | 0.82 | KDM4E (0.33) | LMNAKMT2AKDM4EMAPTCYP1A2 | |
| SCHEMBL9796571 | 0.80 | NR4A2 (0.41) | GSK3BMAOB | |
| SCHEMBL9796308 | 0.80 | SCN9A (0.42) | MAT2AGSK3BTSHR | |
| SCHEMBL9796435 | 0.80 | PGR (0.45) | GSK3BKMT2AMAPTALPL | |
| SCHEMBL6050601 | 0.80 | ALDH1A1 (0.45) | LMNAKMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4997840-A | Quinolone sulphonates having antihypertensive activity | THE BOOTS COMPANY, PLC (GB) | 1991-03-05 | — | — | US | disclosed |
| EP-0330340-A1 | Therapeutic agents | The Boots Company PLC (GB) | 1989-08-30 | — | — | EP | disclosed |
| WO-1989007593-A1 | THERAPEUTIC AGENTS | THE BOOTS COMPANY PLC (GB) | 1989-08-24 | — | — | WO | disclosed |