Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GGPS1 | O95749 | 1/20 | 0.61 |
| ▸ | FDPS | P14324 | 1/20 | 0.61 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 3/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | MIF | P14174 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12732656 | 0.87 | GGPS1 (0.60) | GGPS1FDPSGPR84PKMDRD4 | |
| SCHEMBL12806413 | 0.83 | GGPS1 (0.56) | GGPS1FDPSGPR84PKMDRD4 | |
| SCHEMBL4716835 | 0.81 | GGPS1 (0.58) | GGPS1FDPSGPR84PKMDRD4 | |
| SCHEMBL14290281 | 0.78 | KDM4E (0.47) | GGPS1FDPSPKMFLT3NPC1 | |
| SCHEMBL24178777 | 0.78 | GGPS1 (0.51) | GGPS1FDPSGPR84PKMDRD4 | |
| SCHEMBL2017760 | 0.78 | GGPS1 (0.53) | GGPS1FDPSGPR84PKMDRD4 | |
| SCHEMBL8360107 | 0.78 | GGPS1 (0.53) | GGPS1FDPSGPR84PKMDRD4 | |
| SCHEMBL4271794 | 0.77 | GGPS1 (0.65) | GGPS1FDPSGPR84PKMDRD4 | |
| Hydrochloric Acid SCHEMBL29899404 | 0.76 | GGPS1 (0.51) | GGPS1FDPSGPR84PKMDRD4 | |
| Minodronic Acid SCHEMBL145238 | 0.76 | FDPS (1.00) | GGPS1FDPSGPR84DRD4DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1448561-B1 | BETA 3 ADRENERGIC AGONISTS | LILLY CO ELI (US) | 2008-02-20 | — | — | EP | disclosed |
| US-7265127-B2 | β3 adrenergic agonists | ELI LILLY AND COMPANY (US) | 2007-09-04 | — | — | US | disclosed |
| US-7265127-B2 | β3 adrenergic agonists | ELI LILLY AND COMPANY (US) | 2007-09-04 | — | — | US | disclosed |
| US-7253181-B2 | β3 adrenergic agonists | ELI LILLY AND COMPANY (US) | 2007-08-07 | — | — | US | disclosed |
| US-7253181-B2 | β3 adrenergic agonists | ELI LILLY AND COMPANY (US) | 2007-08-07 | — | — | US | disclosed |
| US-7241772-B2 | β3 adrenergic agonists | ELI LILLY AND COMPANY (US) | 2007-07-10 | — | — | US | disclosed |
| US-7241772-B2 | β3 adrenergic agonists | ELI LILLY AND COMPANY (US) | 2007-07-10 | — | — | US | disclosed |
| US-7205407-B2 | 3-Substituted oxindole β3 agonists | ELI LILLY AND COMPANY (US) | 2007-04-17 | — | — | US | disclosed |
| US-7205407-B2 | 3-Substituted oxindole β3 agonists | ELI LILLY AND COMPANY (US) | 2007-04-17 | — | — | US | disclosed |
| US-5001132-A | Phenyloxypropanolamine derivatives and their application in therapeutics | SYNTHELABO (FR) | 1991-03-19 | — | — | US | disclosed |
| EP-0370852-A1 | Phenyloxypropanolamines, their preparation and therapeutical use | SYNTHELABO (FR) | 1990-05-30 | — | — | EP | disclosed |