Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.47 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL9806189 | 0.95 | MTNR1B (0.48) | CYP3A4CYP2D6CHRNA7MTNR1B | |
| SCHEMBL9797437 | 0.91 | CYP3A4 (0.50) | CYP3A4CYP2D6CHRNA7MTNR1B | |
| SCHEMBL9806155 | 0.89 | MTNR1B (0.51) | CYP3A4CYP2D6MTNR1B | |
| SCHEMBL10416566 | 0.88 | NR1I2 (0.45) | CYP3A4CYP2D6 | |
| SCHEMBL9806154 | 0.88 | GRIN1 (0.55) | CYP3A4CYP2D6 | |
| Hydrochloric Acid SCHEMBL9806147 | 0.87 | MAOA (0.44) | CYP3A4CYP2D6 | |
| SCHEMBL9797731 | 0.84 | CYP3A4 (0.67) | CYP3A4CYP2D6CHRNA7 | |
| SCHEMBL9806164 | 0.84 | ABCB1 (0.50) | CYP3A4CYP2D6MTNR1B | |
| Fumaric Acid SCHEMBL9797372 | 0.83 | TRPV1 (0.47) | CYP3A4CYP2D6MTNR1B | |
| Maleic Acid SCHEMBL9797355 | 0.83 | TRPV1 (0.47) | CYP3A4CYP2D6MTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4988690-A | Antidepressants | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1991-01-29 | — | — | US | claimed |
| US-4935418-A | Medical compositions of 1-aryloxy-2,3,4,5-tetrahydro-3-benzazepines and use thereof | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1990-06-19 | — | — | US | claimed |
| US-4794181-A | ANTIDEPRESSANTS, ANALGESICS | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1988-12-27 | — | — | US | claimed |
| US-5059688-A | 1-aryloxy-2,3,4,5-tetrahydro-3-benzazepine preparation | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1991-10-22 | — | — | US | disclosed |
| US-4988690-A | Antidepressants | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1991-01-29 | — | — | US | disclosed |
| US-4935418-A | Medical compositions of 1-aryloxy-2,3,4,5-tetrahydro-3-benzazepines and use thereof | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1990-06-19 | — | — | US | disclosed |
| US-4794181-A | ANTIDEPRESSANTS, ANALGESICS | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1988-12-27 | — | — | US | disclosed |
| EP-0096838-B1 | 1-ARYLOXY-2,3,4,5-TETRAHYDRO-3-BENZAZEPINES, A PROCESS FOR PREPARING THE SAME AND THEIR USE AS MEDICAMENTS | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1987-04-01 | — | — | EP | disclosed |
| EP-0096838-A1 | 1-Aryloxy-2,3,4,5-tetrahydro-3-benzazepines, a process for preparing the same and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1983-12-28 | — | — | EP | disclosed |