Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 2/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.39 |
| ▸ | TRPM8 | Q7Z2W7 | 7/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.36 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.36 |
| ▸ | SLC9A3 | P48764 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9797258 | 0.89 | SLC6A2 (0.40) | SLC6A2SLC6A4TRPM8NPSR1HDAC3 | |
| SCHEMBL10803907 | 0.89 | KMT2A (0.43) | NPSR1HDAC1HDAC8MEN1KMT2A | |
| SCHEMBL9797190 | 0.86 | SLC6A2 (0.41) | SLC6A2SLC6A4TRPM8HDAC3HDAC1 | |
| SCHEMBL9797531 | 0.86 | SIGMAR1 (0.44) | SLC6A2SLC6A4TRPM8HDAC3HDAC1 | |
| Bromide SCHEMBL9797428 | 0.85 | SIGMAR1 (0.43) | SLC6A2SLC6A4TRPM8HDAC3HDAC1 | |
| SCHEMBL9797266 | 0.84 | SIGMAR1 (0.47) | — | |
| SCHEMBL9797348 | 0.84 | GRIN1 (0.40) | SLC6A2SLC6A4TRPM8HDAC3HDAC1 | |
| SCHEMBL9797467 | 0.83 | SLC6A2 (0.48) | SLC6A2SLC6A4TRPM8NPC1MAPK1 | |
| SCHEMBL9797184 | 0.82 | SIGMAR1 (0.45) | SLC6A2SLC6A4TRPM8HDAC3HDAC1 | |
| SCHEMBL9797624 | 0.82 | SLC6A4 (0.47) | SLC6A2SLC6A4MAPTHDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4988690-A | Antidepressants | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1991-01-29 | — | — | US | claimed |
| US-5059688-A | 1-aryloxy-2,3,4,5-tetrahydro-3-benzazepine preparation | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1991-10-22 | — | — | US | disclosed |
| US-4988690-A | Antidepressants | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1991-01-29 | — | — | US | disclosed |
| US-4935418-A | Medical compositions of 1-aryloxy-2,3,4,5-tetrahydro-3-benzazepines and use thereof | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1990-06-19 | — | — | US | disclosed |
| US-4794181-A | ANTIDEPRESSANTS, ANALGESICS | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1988-12-27 | — | — | US | disclosed |
| EP-0096838-B1 | 1-ARYLOXY-2,3,4,5-TETRAHYDRO-3-BENZAZEPINES, A PROCESS FOR PREPARING THE SAME AND THEIR USE AS MEDICAMENTS | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1987-04-01 | — | — | EP | disclosed |
| EP-0096838-A1 | 1-Aryloxy-2,3,4,5-tetrahydro-3-benzazepines, a process for preparing the same and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1983-12-28 | — | — | EP | disclosed |
| EP-0042097-B1 | PROCESS FOR THE REACTIVATION OF SUPPORT CATALYSTS THAT CONTAIN PALLADIUM OR PLATINUM, COPPER AND TELLURIUM | BASF Aktiengesellschaft (DE) | 1983-06-22 | — | — | EP | disclosed |