Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 2/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.40 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.39 |
| ▸ | SLC7A5 | Q01650 | 4/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.38 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9797190 | 0.94 | SLC6A2 (0.41) | GRIN1GRIN2BSIGMAR1SLC6A2SLC6A4 | |
| SCHEMBL9797531 | 0.87 | SIGMAR1 (0.44) | SIGMAR1SLC6A2SLC6A4HDAC3HDAC1 | |
| SCHEMBL9797624 | 0.87 | SLC6A4 (0.47) | GRIN1GRIN2BSIGMAR1SLC6A2SLC6A4 | |
| Bromide SCHEMBL9797428 | 0.86 | SIGMAR1 (0.43) | SIGMAR1SLC6A2SLC6A4HDAC3HDAC1 | |
| Hydrochloric Acid SCHEMBL9797883 | 0.86 | SLC6A4 (0.46) | GRIN1GRIN2BSIGMAR1SLC6A2SLC6A4 | |
| SCHEMBL9797266 | 0.85 | SIGMAR1 (0.47) | GRIN1GRIN2BSIGMAR1 | |
| SCHEMBL9797294 | 0.84 | SLC6A2 (0.39) | SLC6A2SLC6A4HDAC3HDAC1HDAC8 | |
| SCHEMBL9797467 | 0.84 | SLC6A2 (0.48) | SIGMAR1SLC6A2SLC6A4HDAC3HDAC1 | |
| SCHEMBL9797496 | 0.83 | SLC6A2 (0.45) | SIGMAR1SLC6A2SLC6A4HDAC3HDAC1 | |
| SCHEMBL9797184 | 0.83 | SIGMAR1 (0.45) | SIGMAR1SLC6A2SLC6A4HDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4988690-A | Antidepressants | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1991-01-29 | — | — | US | claimed |
| EP-0096838-B1 | 1-ARYLOXY-2,3,4,5-TETRAHYDRO-3-BENZAZEPINES, A PROCESS FOR PREPARING THE SAME AND THEIR USE AS MEDICAMENTS | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1987-04-01 | — | — | EP | claimed |
| US-5059688-A | 1-aryloxy-2,3,4,5-tetrahydro-3-benzazepine preparation | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1991-10-22 | — | — | US | disclosed |
| US-4988690-A | Antidepressants | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1991-01-29 | — | — | US | disclosed |
| US-4935418-A | Medical compositions of 1-aryloxy-2,3,4,5-tetrahydro-3-benzazepines and use thereof | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1990-06-19 | — | — | US | disclosed |
| US-4794181-A | ANTIDEPRESSANTS, ANALGESICS | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1988-12-27 | — | — | US | disclosed |
| EP-0096838-B1 | 1-ARYLOXY-2,3,4,5-TETRAHYDRO-3-BENZAZEPINES, A PROCESS FOR PREPARING THE SAME AND THEIR USE AS MEDICAMENTS | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1987-04-01 | — | — | EP | disclosed |
| EP-0096838-A1 | 1-Aryloxy-2,3,4,5-tetrahydro-3-benzazepines, a process for preparing the same and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1983-12-28 | — | — | EP | disclosed |