Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | DRD1 | P21728 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.39 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | LTA4H | P09960 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10954592 | 0.88 | SLC6A4 (0.41) | SLC6A2SLC6A4SLC6A3MEN1KMT2A | |
| SCHEMBL9797496 | 0.87 | SLC6A2 (0.45) | HDAC1HDAC8SLC6A2SLC6A4DRD1 | |
| Hydrochloric Acid SCHEMBL9797168 | 0.86 | SLC6A2 (0.44) | HDAC1HDAC8SLC6A2SLC6A4DRD1 | |
| SCHEMBL10416077 | 0.85 | CYP3A4 (0.51) | DRD1KMT2AMCHR1 | |
| Hydrochloric Acid SCHEMBL9806168 | 0.84 | CYP3A4 (0.50) | DRD1KMT2AMCHR1 | |
| SCHEMBL9797358 | 0.84 | PRMT5 (0.42) | HDAC1HDAC8SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL9797639 | 0.82 | SIGMAR1 (0.46) | SLC6A2SLC6A3DRD1DRD2SIGMAR1 | |
| SCHEMBL9797486 | 0.82 | MEN1 (0.42) | DRD1MEN1KMT2ADRD2SIGMAR1 | |
| SCHEMBL10803907 | 0.81 | KMT2A (0.43) | HDAC1HDAC8DRD1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL9797661 | 0.81 | SIGMAR1 (0.47) | DRD1DRD2SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5059688-A | 1-aryloxy-2,3,4,5-tetrahydro-3-benzazepine preparation | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1991-10-22 | — | — | US | disclosed |
| US-4988690-A | Antidepressants | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1991-01-29 | — | — | US | disclosed |
| US-4935418-A | Medical compositions of 1-aryloxy-2,3,4,5-tetrahydro-3-benzazepines and use thereof | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1990-06-19 | — | — | US | disclosed |
| US-4794181-A | ANTIDEPRESSANTS, ANALGESICS | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1988-12-27 | — | — | US | disclosed |
| EP-0096838-B1 | 1-ARYLOXY-2,3,4,5-TETRAHYDRO-3-BENZAZEPINES, A PROCESS FOR PREPARING THE SAME AND THEIR USE AS MEDICAMENTS | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1987-04-01 | — | — | EP | disclosed |
| EP-0096838-A1 | 1-Aryloxy-2,3,4,5-tetrahydro-3-benzazepines, a process for preparing the same and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1983-12-28 | — | — | EP | disclosed |