Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | DRD1 | P21728 | 8/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | DRD5 | P21918 | 4/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.39 |
| ▸ | THPO | P40225 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9797504 | 0.86 | SLC6A2 (0.46) | MEN1KMT2ADRD1DRD5SIGMAR1 | |
| SCHEMBL9797639 | 0.85 | SIGMAR1 (0.46) | DRD1HTR2ADRD5SIGMAR1CYP2D6 | |
| SCHEMBL9154713 | 0.85 | SLC6A4 (0.38) | DRD1SIGMAR1 | |
| SCHEMBL9797369 | 0.85 | SIGMAR1 (0.46) | MEN1KMT2ASIGMAR1 | |
| SCHEMBL9154863 | 0.84 | FADS1 (0.38) | MEN1KMT2ADRD1 | |
| SCHEMBL10416687 | 0.84 | CYP3A4 (0.54) | DRD1DRD5CYP2D6CYP3A4 | |
| Hydrochloric Acid SCHEMBL9797661 | 0.84 | SIGMAR1 (0.47) | DRD1HTR2ADRD5SIGMAR1CYP2D6 | |
| SCHEMBL9797472 | 0.82 | SIGMAR1 (0.47) | SIGMAR1CYP2D6 | |
| SCHEMBL9797229 | 0.82 | LMNA (0.40) | MEN1KMT2ASIGMAR1 | |
| SCHEMBL9797340 | 0.82 | HDAC1 (0.41) | MEN1KMT2ADRD1SIGMAR1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4988690-A | Antidepressants | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1991-01-29 | — | — | US | claimed |
| US-5059688-A | 1-aryloxy-2,3,4,5-tetrahydro-3-benzazepine preparation | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1991-10-22 | — | — | US | disclosed |
| US-4988690-A | Antidepressants | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1991-01-29 | — | — | US | disclosed |
| US-4935418-A | Medical compositions of 1-aryloxy-2,3,4,5-tetrahydro-3-benzazepines and use thereof | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1990-06-19 | — | — | US | disclosed |
| US-4794181-A | ANTIDEPRESSANTS, ANALGESICS | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1988-12-27 | — | — | US | disclosed |
| EP-0096838-B1 | 1-ARYLOXY-2,3,4,5-TETRAHYDRO-3-BENZAZEPINES, A PROCESS FOR PREPARING THE SAME AND THEIR USE AS MEDICAMENTS | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1987-04-01 | — | — | EP | disclosed |
| EP-0096838-A1 | 1-Aryloxy-2,3,4,5-tetrahydro-3-benzazepines, a process for preparing the same and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1983-12-28 | — | — | EP | disclosed |