Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPRT1 | P00492 | 2/20 | 0.50 |
| ▸ | TYMS | P04818 | 9/20 | 0.33 |
| ▸ | DHFR | P00374 | 7/20 | 0.33 |
| ▸ | NOS1 | P29475 | 5/20 | 0.32 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.31 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.31 |
| ▸ | PNP | P00491 | 1/20 | 0.31 |
| ▸ | NOS3 | P29474 | 1/20 | 0.30 |
| ▸ | NOS2 | P35228 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9799127 | 0.91 | HPRT1 (0.43) | HPRT1PNP | |
| SCHEMBL9798139 | 0.88 | HPRT1 (0.39) | HPRT1TYMSDHFRNOS1CDK5 | |
| SCHEMBL9799100 | 0.81 | HPRT1 (0.48) | HPRT1TYMSNOS1PNPNOS3 | |
| SCHEMBL9798158 | 0.81 | PNP (0.50) | HPRT1NOS1PNP | |
| SCHEMBL10509301 | 0.78 | HPRT1 (0.50) | HPRT1TYMSDHFRPNP | |
| SCHEMBL2128394 | 0.78 | HPRT1 (0.49) | HPRT1TYMSNOS1PNP | |
| SCHEMBL10508430 | 0.77 | HPRT1 (0.48) | HPRT1TYMSPNP | |
| SCHEMBL10643903 | 0.76 | HPRT1 (0.38) | HPRT1TYMSNOS1PNPNOS3 | |
| SCHEMBL9799070 | 0.76 | PNP (0.50) | HPRT1PNP | |
| SCHEMBL10507676 | 0.76 | HPRT1 (0.48) | HPRT1PNP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4772606-A | AUTOIMMUNE DISEASES, ORGAN TRANSPLANTS | WARNER-LAMBERT COMPANY (US) | 1988-09-20 | — | — | US | claimed |
| EP-0178178-A2 | Purine derivatives | WARNER-LAMBERT COMPANY (US) | 1986-04-16 | — | — | EP | claimed |
| US-5051429-A | For treatment of autoimmune diseases such as arthritis, lupus, antiinflammatory agents, multiple sclerosis, diabetes and viral diseases | WARNER-LAMBERT CO. (US) | 1991-09-24 | — | — | US | disclosed |
| US-4952693-A | TREATING AUTOIMMUNE DISEASES | WARNER-LAMBERT COMPANY (US) | 1990-08-28 | — | — | US | disclosed |
| US-4772606-A | AUTOIMMUNE DISEASES, ORGAN TRANSPLANTS | WARNER-LAMBERT COMPANY (US) | 1988-09-20 | — | — | US | disclosed |
| EP-0178178-A2 | Purine derivatives | WARNER-LAMBERT COMPANY (US) | 1986-04-16 | — | — | EP | disclosed |