Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY1R | P25929 | 1/20 | 0.59 |
| ▸ | NPY2R | P49146 | 1/20 | 0.59 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | ADRB1 | P08588 | 4/20 | 0.57 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.57 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.57 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.57 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.57 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.57 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4456681 | 0.86 | NPY1R (0.67) | NPY1RNPY2RPMP22NPSR1TDP1 | |
| SCHEMBL9798727 | 0.84 | TDP1 (0.60) | NPY1RNPY2RPMP22NPSR1TDP1 | |
| SCHEMBL7286484 | 0.84 | NPY1R (0.75) | NPY1RNPY2RPMP22NPSR1TDP1 | |
| SCHEMBL20887451 | 0.84 | ADRB1 (0.61) | NPY1RNPY2RPMP22NPSR1TDP1 | |
| SCHEMBL8892157 | 0.84 | ADRB1 (0.66) | NPY1RNPY2RPMP22NPSR1TDP1 | |
| SCHEMBL2473791 | 0.83 | ADRB1 (0.65) | NPY1RNPY2RPMP22NPSR1TDP1 | |
| SCHEMBL11320142 | 0.82 | ADRB1 (0.63) | NPY1RNPY2RPMP22NPSR1TDP1 | |
| SCHEMBL8746468 | 0.81 | ADRB1 (0.56) | NPY1RNPY2RPMP22NPSR1TDP1 | |
| SCHEMBL8746455 | 0.79 | NPY1R (0.53) | NPY1RNPY2RPMP22NPSR1TDP1 | |
| Fumaric Acid SCHEMBL10909713 | 0.79 | NPY1R (0.58) | NPY1RNPY2RPMP22NPSR1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0229947-B1 | NOVEL CRYSTALLINE SALTS OF ARYLOXY-PROPANOLAMINES, THEIR PREPARATION AND THEIR USE | RORER INTERNATIONAL (OVERSEAS) INC. (US) | 1991-03-13 | — | — | EP | disclosed |
| US-4849530-A | Process for the preparation of crystalline salts or aryloxy-propanolamines | RORER PHARMACEUTICAL CORPORATION (US) | 1989-07-18 | — | — | US | disclosed |
| US-4767784-A | DIPHENYLACETATES | RORER PHARMACEUTICAL CORPORATION | 1988-08-30 | — | — | US | disclosed |
| EP-0229947-A1 | Novel crystalline salts of aryloxy-propanolamines, their preparation and their use | RORER INTERNATIONAL (OVERSEAS) INC. (US) | 1987-07-29 | — | — | EP | disclosed |