Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 1/20 | 0.43 |
| ▸ | CES2 | O00748 | 1/20 | 0.43 |
| ▸ | CES1 | P23141 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | MGAM | O43451 | 1/20 | 0.35 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | SI | P14410 | 1/20 | 0.35 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10610685 | 0.83 | CES2 (0.41) | HMGCRCES2CES1ALDH1A1USP2 | |
| SCHEMBL10612486 | 0.83 | MAPT (0.50) | CES2CES1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL4681920 | 0.81 | HMGCR (0.46) | HMGCRCES2CES1ALDH1A1USP2 | |
| SCHEMBL10611755 | 0.79 | HMGCR (0.37) | HMGCRALDH1A1USP2HSD17B10SMN1; SMN2 | |
| SCHEMBL10610695 | 0.78 | HMGCR (0.45) | HMGCRALDH1A1USP2HSD17B10SMN1; SMN2 | |
| SCHEMBL10610689 | 0.77 | HMGCR (0.40) | HMGCRALDH1A1USP2HSD17B10RAB9A | |
| SCHEMBL10609399 | 0.77 | HMGCR (0.40) | HMGCRALDH1A1USP2HSD17B10RAB9A | |
| SCHEMBL10527444 | 0.76 | HMGCR (0.45) | HMGCRALDH1A1USP2HSD17B10RAB9A | |
| SCHEMBL9726661 | 0.75 | HMGCR (0.47) | HMGCRALDH1A1USP2HSD17B10RAB9A | |
| SCHEMBL10386594 | 0.74 | HMGCR (0.47) | HMGCRALDH1A1USP2HSD17B10RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5068346-A | Anticholesterol agents | BRISTOL-MYERS COMPANY (US) | 1991-11-26 | — | — | US | disclosed |
| WO-1988006584-A1 | ANTIHYPERCHOLESTEROLEMIC TETRAZOLE COMPOUNDS | BRISTOL-MYERS COMPANY (US) | 1988-09-07 | — | — | WO | disclosed |