Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | CES2 | O00748 | 2/20 | 0.49 |
| ▸ | CES1 | P23141 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.41 |
| ▸ | FEN1 | P39748 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 3/20 | 0.40 |
| ▸ | CA2 | P00918 | 3/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | MGAM | O43451 | 1/20 | 0.39 |
| ▸ | F12 | P00748 | 1/20 | 0.39 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.39 |
| ▸ | SI | P14410 | 1/20 | 0.39 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9799130 | 0.83 | HMGCR (0.43) | MAPTCES2CES1ALDH1A1GAA | |
| SCHEMBL4683697 | 0.82 | ALDH1A1 (0.49) | MAPTCES2CES1ALDH1A1ERCC5 | |
| SCHEMBL10425548 | 0.82 | ALDH1A1 (0.43) | MAPTCES2CES1ALDH1A1ERCC5 | |
| SCHEMBL18982976 | 0.75 | CES2 (0.72) | MAPTCES2CES1KMT2ARAB9A | |
| SCHEMBL4685242 | 0.74 | ALDH1A1 (0.45) | CES2CES1ALDH1A1ERCC5FEN1 | |
| SCHEMBL9726963 | 0.74 | TCF4 (0.46) | MAPTALDH1A1ERCC5FEN1RAB9A | |
| SCHEMBL10611755 | 0.71 | HMGCR (0.37) | MAPTALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL10385010 | 0.71 | NQO2 (0.43) | MAPTCES2CES1ALDH1A1ERCC5 | |
| SCHEMBL10385011 | 0.71 | NQO2 (0.43) | MAPTCES2CES1ALDH1A1ERCC5 | |
| SCHEMBL9726718 | 0.70 | HMGCR (0.43) | MAPTALDH1A1ERCC5FEN1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1988006584-A1 | ANTIHYPERCHOLESTEROLEMIC TETRAZOLE COMPOUNDS | BRISTOL-MYERS COMPANY (US) | 1988-09-07 | — | — | WO | disclosed |