Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | ADRB3 | P13945 | 6/20 | 0.45 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11459286 | 0.89 | KDM4E (0.59) | ALDH1A1KDM4EL3MBTL1MEN1KMT2A | |
| SCHEMBL11483076 | 0.88 | ALDH1A1 (0.53) | ALDH1A1KDM4EHSD17B10L3MBTL1TSHR | |
| SCHEMBL11451326 | 0.88 | ALDH1A1 (0.53) | ALDH1A1KDM4EHSD17B10L3MBTL1TSHR | |
| Hydrochloric Acid SCHEMBL11477462 | 0.87 | ALDH1A1 (0.55) | ALDH1A1KDM4EHSD17B10L3MBTL1TSHR | |
| SCHEMBL8976776 | 0.85 | KDM4E (0.77) | ALDH1A1KDM4EL3MBTL1KMT2ATAAR1 | |
| SCHEMBL9061582 | 0.85 | KDM4E (0.77) | ALDH1A1KDM4EL3MBTL1KMT2ATAAR1 | |
| SCHEMBL11346266 | 0.85 | ADRB3 (0.59) | ADRB3ADRB1 | |
| SCHEMBL10875863 | 0.82 | KDM4E (0.63) | ALDH1A1KDM4EHSD17B10L3MBTL1TSHR | |
| SCHEMBL11284376 | 0.82 | HPGD (0.46) | ALDH1A1MEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL11373728 | 0.81 | MEN1 (0.53) | ALDH1A1KDM4EL3MBTL1TSHRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0170135-B1 | NOVEL MORPHOLINES | BEECHAM GROUP PLC (GB) | 1991-03-20 | — | — | EP | disclosed |
| US-4596800-A | Hypoglycaemic agents | BEECHAM GROUP P.L.C. (GB) | 1986-06-24 | — | — | US | disclosed |
| EP-0170135-A1 | Novel Morpholines | BEECHAM GROUP PLC (GB) | 1986-02-05 | — | — | EP | disclosed |