Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 15/20 | 0.74 |
| ▸ | ADRB3 | P13945 | 13/20 | 0.74 |
| ▸ | ADRB1 | P08588 | 8/20 | 0.74 |
| ▸ | GLA | P06280 | 1/20 | 0.74 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.61 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.61 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.61 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.59 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9631209 | 0.91 | ADRB3 (0.74) | ADRB2ADRB3ADRB1GLACYP2D6 | |
| SCHEMBL10860881 | 0.90 | ADRB2 (0.60) | ADRB2ADRB3ADRB1GLACYP2D6 | |
| SCHEMBL10933710 | 0.90 | ADRB2 (0.60) | ADRB2ADRB3ADRB1GLACYP2D6 | |
| Ethane SCHEMBL11152387 | 0.90 | ADRB3 (0.73) | ADRB2ADRB3ADRB1GLACYP2D6 | |
| SCHEMBL11148041 | 0.90 | ADRB3 (0.64) | ADRB2ADRB3ADRB1GLACYP2D6 | |
| Hydrochloric Acid SCHEMBL10861322 | 0.90 | ADRB2 (0.59) | ADRB2ADRB3ADRB1GLACYP2D6 | |
| SCHEMBL10898514 | 0.88 | ADRB3 (0.61) | ADRB2ADRB3ADRB1GLACYP2D6 | |
| SCHEMBL10937612 | 0.87 | ADRB3 (0.57) | ADRB2ADRB3ADRB1GLACYP2D6 | |
| SCHEMBL10978911 | 0.87 | ADRB2 (0.63) | ADRB2ADRB3ADRB1GLACYP2D6 | |
| SCHEMBL10811089 | 0.86 | ADRB2 (0.55) | ADRB2ADRB3ADRB1GLACYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0085514-A2 | Compositions comprising a beta-antagonist and a beta-agonist, their preparation, and their use in treating obese humans and animals | BEECHAM GROUP PLC (GB) | 1983-08-10 | — | — | EP | claimed |
| US-4338333-A | ANTIOBESITY, HYPOGLYCEMIC | BEECHAM GROUP LIMITED (GB) | 1982-07-06 | — | — | US | claimed |
| EP-0170135-B1 | NOVEL MORPHOLINES | BEECHAM GROUP PLC (GB) | 1991-03-20 | — | — | EP | disclosed |
| US-4803293-A | Tertiary amines | BEECHAM GROUP PLC (GB) | 1989-02-07 | — | — | US | disclosed |
| EP-0142102-B1 | TERTIARY AMINES | BEECHAM GROUP PLC (GB) | 1987-09-23 | — | — | EP | disclosed |
| EP-0236624-A2 | Substituted phenyl ethanol amines, processes for their preparation and pharmaceutical compositions containing them | BEECHAM GROUP PLC (GB) | 1987-09-16 | — | — | EP | disclosed |
| US-4596800-A | Hypoglycaemic agents | BEECHAM GROUP P.L.C. (GB) | 1986-06-24 | — | — | US | disclosed |
| EP-0170135-A1 | Novel Morpholines | BEECHAM GROUP PLC (GB) | 1986-02-05 | — | — | EP | disclosed |
| EP-0142102-A2 | Tertiary amines | BEECHAM GROUP PLC (GB) | 1985-05-22 | — | — | EP | disclosed |
| US-4382958-A | Secondary amines and compositions for treatment of hypoglycaemia or obesity | BEECHAM GROUP LIMITED (GB) | 1983-05-10 | — | — | US | disclosed |
| EP-0070133-A2 | Secondary phenylethanol amines, processes for their preparation and their pharmaceutical application | BEECHAM GROUP PLC (GB) | 1983-01-19 | — | — | EP | disclosed |
| EP-0023385-B1 | ETHANAMINE DERIVATIVES, THEIR PREPARATION AND USE IN PHARMACEUTICAL COMPOSITIONS | BEECHAM GROUP PLC (GB) | 1982-12-15 | — | — | EP | disclosed |
| US-4338333-A | ANTIOBESITY, HYPOGLYCEMIC | BEECHAM GROUP LIMITED (GB) | 1982-07-06 | — | — | US | disclosed |
| EP-0052963-A1 | Secondary amines | BEECHAM GROUP PLC (GB) | 1982-06-02 | — | — | EP | disclosed |
| EP-0023385-A1 | Ethanamine derivatives, their preparation and use in pharmaceutical compositions | BEECHAM GROUP PLC (GB) | 1981-02-04 | — | — | EP | disclosed |