Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.40 |
| ▸ | FEN1 | P39748 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 5/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9799533 | 0.89 | FEN1 (0.50) | CYP2C19PDE4BPDE4DFEN1PDE4A | |
| SCHEMBL9799505 | 0.86 | MEN1 (0.47) | MAPTMEN1CYP1A2HPGDCYP2C19 | |
| SCHEMBL9799483 | 0.82 | PDE4A (0.46) | MAPTMEN1CYP1A2HPGDCYP2C19 | |
| SCHEMBL9535601 | 0.78 | MAPT (0.50) | MAPTMEN1CYP1A2HPGDCYP2C19 | |
| SCHEMBL9726939 | 0.77 | MAPT (0.43) | MAPTMEN1CYP1A2HPGDCYP2C19 | |
| SCHEMBL9799632 | 0.76 | FEN1 (0.50) | MAPTHPGDCYP2C19PDE4BPDE4D | |
| SCHEMBL9799534 | 0.75 | MAPT (0.50) | MAPTMEN1CYP1A2HPGDCYP2C19 | |
| SCHEMBL10379090 | 0.74 | MAPT (0.46) | MAPTMEN1CYP1A2HPGDCYP2C19 | |
| SCHEMBL9629146 | 0.74 | MAPT (0.49) | MAPTMEN1CYP1A2HPGDCYP2C19 | |
| SCHEMBL10377111 | 0.72 | MAPT (0.47) | MAPTMEN1CYP1A2HPGDCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4996212-A | Antiinflammatory and anti-hyperproliferative compounds | SCHERING CORPORATION (US) | 1991-02-26 | — | — | US | claimed |
| US-4859669-A | Antiinflammatory and anti-hyperproliferative naphthyridin-4-ones | SCHERING CORPORATION (US) | 1989-08-22 | — | — | US | disclosed |