Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FEN1 | P39748 | 1/20 | 0.50 |
| ▸ | PDE4A | P27815 | 7/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | PDE1A | P54750 | 1/20 | 0.43 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | LDHA | P00338 | 1/20 | 0.41 |
| ▸ | LOXL3 | P58215 | 1/20 | 0.40 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.40 |
| ▸ | REN | P00797 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9799715 | 0.90 | ALDH1A1 (0.47) | FEN1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9799505 | 0.85 | MEN1 (0.47) | FEN1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9799506 | 0.84 | PDE4A (0.54) | FEN1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9799533 | 0.84 | FEN1 (0.50) | FEN1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9799507 | 0.79 | PDE4A (0.50) | FEN1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9535305 | 0.79 | FEN1 (0.55) | FEN1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9532938 | 0.79 | FEN1 (0.55) | FEN1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9799483 | 0.77 | PDE4A (0.46) | FEN1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9799482 | 0.76 | MAPT (0.43) | FEN1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9799616 | 0.75 | PDE4A (0.53) | FEN1PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4996212-A | Antiinflammatory and anti-hyperproliferative compounds | SCHERING CORPORATION (US) | 1991-02-26 | — | — | US | claimed |
| US-4996212-A | Antiinflammatory and anti-hyperproliferative compounds | SCHERING CORPORATION (US) | 1991-02-26 | — | — | US | disclosed |
| US-4859669-A | Antiinflammatory and anti-hyperproliferative naphthyridin-4-ones | SCHERING CORPORATION (US) | 1989-08-22 | — | — | US | disclosed |