Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 2/20 | 0.46 |
| ▸ | CNR1 | P21554 | 6/20 | 0.44 |
| ▸ | CNR2 | P34972 | 6/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | DHPS | P49366 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CRHBP | P24387 | 1/20 | 0.40 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5872001 | 0.73 | GAA (0.42) | CNR1CNR2PDE4BPDE4DGAA | |
| SCHEMBL1945900 | 0.66 | SMN1; SMN2 (0.55) | PDE4AMEN1KMT2ATSHRSMN1; SMN2 | |
| SCHEMBL1522680 | 0.66 | DDB1 (0.42) | PDE4BPDE4DGAAALOX15MEN1 | |
| SCHEMBL1522771 | 0.66 | DDB1 (0.42) | PDE4BPDE4DGAAALOX15MEN1 | |
| SCHEMBL7280534 | 0.65 | PDE4A (0.83) | PDE4APDE4BPDE4CPDE4DTSHR | |
| SCHEMBL5871425 | 0.65 | PDE4B (0.42) | PDE4BPDE4DGAAALOX15MEN1 | |
| SCHEMBL1522541 | 0.64 | DDB1 (0.43) | PDE4BPDE4DGAAALOX15MEN1 | |
| SCHEMBL11871647 | 0.63 | FEN1 (0.55) | GAAALOX15MEN1KMT2AATM | |
| SCHEMBL8696469 | 0.63 | MGLL (0.41) | GAAALOX15TSHRALDH1A1DDB1 | |
| SCHEMBL7272788 | 0.63 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4996212-A | Antiinflammatory and anti-hyperproliferative compounds | SCHERING CORPORATION (US) | 1991-02-26 | — | — | US | claimed |
| US-4996212-A | Antiinflammatory and anti-hyperproliferative compounds | SCHERING CORPORATION (US) | 1991-02-26 | — | — | US | disclosed |
| US-4859669-A | Antiinflammatory and anti-hyperproliferative naphthyridin-4-ones | SCHERING CORPORATION (US) | 1989-08-22 | — | — | US | disclosed |