Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | MAOB | P27338 | 3/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5663071 | 0.95 | MAPT (0.53) | MAPTRAB9ASMN1; SMN2MAOBMEN1 | |
| SCHEMBL29678473 | 0.95 | MAPT (0.53) | MAPTRAB9ASMN1; SMN2MAOBMEN1 | |
| SCHEMBL12665719 | 0.88 | RAB9A (0.51) | MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL15293799 | 0.81 | MAOB (0.59) | TDP1L3MBTL1MAOBHDAC1HDAC7 | |
| SCHEMBL16474055 | 0.81 | MAPT (0.51) | MAPTRAB9ASMN1; SMN2MAOBMEN1 | |
| SCHEMBL6790333 | 0.80 | TDP1 (0.71) | TDP1L3MBTL1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL3469500 | 0.80 | MAOB (0.60) | TDP1L3MBTL1MAOBMEN1CYP1A2 | |
| SCHEMBL29263672 | 0.80 | MAOB (0.60) | TDP1L3MBTL1MAOBMEN1CYP1A2 | |
| SCHEMBL20099096 | 0.80 | MAOB (0.60) | TDP1L3MBTL1MAOBMEN1CYP1A2 | |
| SCHEMBL3468557 | 0.80 | MAOB (0.60) | TDP1L3MBTL1MAOBMEN1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4994483-A | 5-substituted-3-aminoalkyl indole derivatives for migraine | GLAXO GROUP LIMITED (GB) | 1991-02-19 | — | — | US | disclosed |
| US-4816470-A | Heterocyclic compounds | GLAXO GROUP LIMITED | 1989-03-28 | — | — | US | disclosed |