Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | KCNQ2 | O43526 | 4/20 | 0.47 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.47 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.47 |
| ▸ | KCNQ4 | P56696 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9800451 | 0.83 | GAA (0.57) | GAAKDM4ESMN1; SMN2ALDH1A1KCNQ2 | |
| SCHEMBL9800495 | 0.83 | GAA (0.52) | GAAKDM4ESMN1; SMN2ALDH1A1KCNQ2 | |
| SCHEMBL9800444 | 0.82 | KLK7 (0.47) | GAAKDM4ESMN1; SMN2ALDH1A1KCNQ2 | |
| SCHEMBL9800485 | 0.73 | FAAH (0.51) | — | |
| SCHEMBL3596195 | 0.73 | CHRM1 (0.55) | GAAKDM4ESMN1; SMN2ALDH1A1TSHR | |
| SCHEMBL2290954 | 0.73 | CRHBP (0.53) | GAAKDM4ESMN1; SMN2ALDH1A1KCNQ2 | |
| SCHEMBL9910968 | 0.72 | KCNQ2 (0.56) | GAAKDM4ESMN1; SMN2ALDH1A1KCNQ2 | |
| SCHEMBL10862172 | 0.71 | KMT2A (0.52) | KDM4ESMN1; SMN2ALDH1A1LMNAMAPK1 | |
| SCHEMBL10862179 | 0.71 | KMT2A (0.52) | KDM4ESMN1; SMN2ALDH1A1LMNAMAPK1 | |
| SCHEMBL7351452 | 0.70 | CHRM1 (0.58) | GAASMN1; SMN2ALDH1A1TSHRL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0224272-B1 | PYRROLIDINYLAMIDE ESTER DERIVATIVE HAVING ANTI-PROLYL ENDOPEPTIDASE ACTIVITY, ITS SYNTHESIS AND USE AND A PHARMACEUTICAL COMPOSITION CONTAINING IT | SUNTORY LIMITED (JP) | 1991-02-06 | — | — | EP | disclosed |
| US-4757083-A | Enzyme inhibitors | SUNTORY LIMITED (JP) | 1988-07-12 | — | — | US | disclosed |
| EP-0224272-A1 | Pyrrolidinylamide ester derivative having anti-prolyl endopeptidase activity, its synthesis and use and a pharmaceutical composition containing it | SUNTORY LIMITED (JP) | 1987-06-03 | — | — | EP | disclosed |