Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9800937 | 1.00 | EPHX2 (0.51) | EPHX2ALDH1A1LMNAHTTMAPK1 | |
| SCHEMBL21292015 | 0.86 | LMNA (0.56) | ALDH1A1LMNAHTTMAPK1GAA | |
| SCHEMBL19420682 | 0.86 | ALDH1A1 (0.58) | ALDH1A1LMNAHTTMAPK1GAA | |
| SCHEMBL20026965 | 0.84 | ALDH1A1 (0.60) | ALDH1A1LMNAHTTMAPK1GAA | |
| SCHEMBL9800913 | 0.84 | EPHX2 (0.55) | EPHX2ALDH1A1HTT | |
| SCHEMBL9800918 | 0.84 | EPHX2 (0.55) | EPHX2ALDH1A1HTT | |
| SCHEMBL22598037 | 0.81 | KMT2A (0.63) | EPHX2ALDH1A1LMNAHTTGAA | |
| SCHEMBL22598038 | 0.81 | KMT2A (0.63) | EPHX2ALDH1A1LMNAHTTGAA | |
| SCHEMBL23505645 | 0.80 | ALDH1A1 (0.53) | ALDH1A1LMNAHTTMAPK1GAA | |
| SCHEMBL9678655 | 0.78 | GAA (0.50) | EPHX2ALDH1A1LMNAHTTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0297610-B1 | N-[(2,6-disubstituted)phenyl]-urea and carbamate inhibitors of acyl-CoA:cholesterol acyl-transferase | WARNER-LAMBERT COMPANY (US) | 1991-03-13 | — | — | EP | disclosed |
| EP-0297610-A1 | N-[(2,6-disubstituted)phenyl]-urea and carbamate inhibitors of acyl-CoA:cholesterol acyl-transferase | WARNER-LAMBERT COMPANY (US) | 1989-01-04 | — | — | EP | disclosed |