Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | TP53 | P04637 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | CCR6 | P51684 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12922443 | 0.79 | KMT2A (0.68) | MEN1KMT2AHSD17B10ALDH1A1MAPT | |
| SCHEMBL19374171 | 0.76 | ALDH1A1 (0.54) | MEN1KMT2AHSD17B10ALDH1A1HPGD | |
| SCHEMBL3174932 | 0.76 | HSD17B10 (0.97) | MEN1KMT2AHSD17B10ALDH1A1HPGD | |
| SCHEMBL9802667 | 0.76 | JAK3 (0.40) | MEN1KMT2AHSD17B10ALDH1A1HPGD | |
| SCHEMBL10836352 | 0.76 | HSD17B10 (0.78) | MEN1KMT2AHSD17B10ALDH1A1HPGD | |
| SCHEMBL12922445 | 0.73 | KMT2A (0.49) | MEN1KMT2AHSD17B10ALDH1A1MAPT | |
| SCHEMBL16433504 | 0.72 | SMPD1 (0.46) | MEN1KMT2AHSD17B10ALDH1A1SMPD1 | |
| SCHEMBL10992739 | 0.72 | HSD17B10 (0.76) | MEN1KMT2AHSD17B10ALDH1A1HPGD | |
| SCHEMBL4152125 | 0.71 | HTR1A (0.76) | MEN1KMT2AHSD17B10ALDH1A1HPGD | |
| SCHEMBL13925801 | 0.71 | HSD17B10 (0.52) | MEN1KMT2AHSD17B10ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5049563-A | 5-hydroxytryptamine receptor antagonists | DUPHAR INTERNATIONAL RESEARCH B.V. (NL) | 1991-09-17 | — | — | US | disclosed |
| EP-0350129-A1 | New annelated indoleketones with an imidazolylalkyl substituent | DUPHAR INTERNATIONAL RESEARCH B.V (NL) | 1990-01-10 | — | — | EP | disclosed |